Aerobic Iron(III)-Catalyzed Direct Thiolation of Imidazo[1,2-a]pyridine with Thiols

Abstract A novel and efficient iron(III)-catalyzed regioselective C-3 sulfenylation of imidazo[1,2-a]pyridines with thiols under oxygen atmosphere has been developed. The reaction proceeds in moderate to good yields with a broad range of substrates, providing a novel, efficient and green route for a...

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Main Authors:	Ling Qin, Hui-bin Wu, Lidong Weng, Qun Shen, Huoji Chen
Format:	Article
Language:	English
Published:	Georg Thieme Verlag KG 2020-04-01
Series:	SynOpen
Subjects:	iron-catalyzed thiolation imidazo[1,2-a]pyridine thiols anticancer activity
Online Access:	http://www.thieme-connect.de/DOI/DOI?10.1055/s-0040-1707517

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spelling	doaj-ea092d0b22c940d3b2464eff5a9f046c2020-11-25T03:31:21ZengGeorg Thieme Verlag KGSynOpen2509-93962020-04-010402172210.1055/s-0040-1707517Aerobic Iron(III)-Catalyzed Direct Thiolation of Imidazo[1,2-a]pyridine with ThiolsLing Qin0Hui-bin Wu1Lidong Weng2Qun Shen3Huoji Chen4Department of Pharmaceutics, Nanfang HospitalDepartment of Pharmaceutics, Nanfang HospitalSchool of Traditional Chinese MedicineSchool of Traditional Chinese MedicineSchool of Traditional Chinese MedicineAbstract A novel and efficient iron(III)-catalyzed regioselective C-3 sulfenylation of imidazo[1,2-a]pyridines with thiols under oxygen atmosphere has been developed. The reaction proceeds in moderate to good yields with a broad range of substrates, providing a novel, efficient and green route for accessing synthetically useful C3-sulfenated imidazo-[1,2-a]pyridines. Moreover, the fluoride-containing C3-sulfenated imidazo-[1,2-a]pyridine 3ai exhibited superior anticancer activity and good safety profiles.http://www.thieme-connect.de/DOI/DOI?10.1055/s-0040-1707517iron-catalyzedthiolationimidazo[1,2-a]pyridinethiolsanticancer activity
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Ling Qin Hui-bin Wu Lidong Weng Qun Shen Huoji Chen
spellingShingle	Ling Qin Hui-bin Wu Lidong Weng Qun Shen Huoji Chen Aerobic Iron(III)-Catalyzed Direct Thiolation of Imidazo[1,2-a]pyridine with Thiols SynOpen iron-catalyzed thiolation imidazo[1,2-a]pyridine thiols anticancer activity
author_facet	Ling Qin Hui-bin Wu Lidong Weng Qun Shen Huoji Chen
author_sort	Ling Qin
title	Aerobic Iron(III)-Catalyzed Direct Thiolation of Imidazo[1,2-a]pyridine with Thiols
title_short	Aerobic Iron(III)-Catalyzed Direct Thiolation of Imidazo[1,2-a]pyridine with Thiols
title_full	Aerobic Iron(III)-Catalyzed Direct Thiolation of Imidazo[1,2-a]pyridine with Thiols
title_fullStr	Aerobic Iron(III)-Catalyzed Direct Thiolation of Imidazo[1,2-a]pyridine with Thiols
title_full_unstemmed	Aerobic Iron(III)-Catalyzed Direct Thiolation of Imidazo[1,2-a]pyridine with Thiols
title_sort	aerobic iron(iii)-catalyzed direct thiolation of imidazo[1,2-a]pyridine with thiols
publisher	Georg Thieme Verlag KG
series	SynOpen
issn	2509-9396
publishDate	2020-04-01
description	Abstract A novel and efficient iron(III)-catalyzed regioselective C-3 sulfenylation of imidazo[1,2-a]pyridines with thiols under oxygen atmosphere has been developed. The reaction proceeds in moderate to good yields with a broad range of substrates, providing a novel, efficient and green route for accessing synthetically useful C3-sulfenated imidazo-[1,2-a]pyridines. Moreover, the fluoride-containing C3-sulfenated imidazo-[1,2-a]pyridine 3ai exhibited superior anticancer activity and good safety profiles.
topic	iron-catalyzed thiolation imidazo[1,2-a]pyridine thiols anticancer activity
url	http://www.thieme-connect.de/DOI/DOI?10.1055/s-0040-1707517
work_keys_str_mv	AT lingqin aerobicironiiicatalyzeddirectthiolationofimidazo12apyridinewiththiols AT huibinwu aerobicironiiicatalyzeddirectthiolationofimidazo12apyridinewiththiols AT lidongweng aerobicironiiicatalyzeddirectthiolationofimidazo12apyridinewiththiols AT qunshen aerobicironiiicatalyzeddirectthiolationofimidazo12apyridinewiththiols AT huojichen aerobicironiiicatalyzeddirectthiolationofimidazo12apyridinewiththiols
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Aerobic Iron(III)-Catalyzed Direct Thiolation of Imidazo[1,2-a]pyridine with Thiols

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