Immune checkpoint blockade therapy for bladder cancer treatment
Bladder cancer remains the most immunogenic and expensive malignant tumor in the United States today. As the 4th leading cause of death from cancer in United States, Immunotherapy blocking immune checkpoints have been recently been applied to many aggressive cancers and changed interventions of ur...
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| Format: | Article |
| Language: | English |
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Korean Urological Association
2016-06-01
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| Series: | Investigative and Clinical Urology |
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| Online Access: | https://www.icurology.org/Synapse/Data/PDFData/2020ICU/icu-57-S98.pdf |
| Summary: | Bladder cancer remains the most immunogenic and expensive malignant tumor in the United States today. As the 4th leading
cause of death from cancer in United States, Immunotherapy blocking immune checkpoints have been recently been applied to
many aggressive cancers and changed interventions of urological cancers including advanced bladder cancer. The applied inhibition
of PD-1–PD-L1 interactions can restore antitumor T-cell activity and enhance the cellular immune attack on antigens. The
overall goals of this short review article are to introduce current cancer immunotherapy and immune checkpoint inhibitors, and to
provide new insight into the underlying mechanisms that block immune checkpoints in tumor microenvironment. Furthermore,
this review will address the preclinical and clinical trials to determine whether bladder cancer patients could benefit from this new
cancer therapy in near future. |
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| ISSN: | 2466-0493 2466-054X |