Evaluation of Inflammatory State in Migraineurs: A Case-control Study
Due to inconclusive findings of previous researches, we aimed to evaluate inflammatory state biomarkers in episodic and chronic migraineurs (EM and CM patients) compared to headache-free controls in the current study. Seventy-one migraine patients and 19 age-sex-matched controls were recruited. Aft...
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Tehran University of Medical Sciences
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doaj-ea156eb521ce4a1e9f6817df544debf82020-11-25T04:12:30ZengTehran University of Medical SciencesIranian Journal of Allergy, Asthma and Immunology1735-15021735-52492020-05-0119S110.18502/ijaai.v19i(s1.r1).28642448Evaluation of Inflammatory State in Migraineurs: A Case-control StudyMansoureh Togha0Soodeh Razeghi Jahromi1Zeinab Ghorbani2Amir Ghaemi3Pegah Rafiee4Department of Headache, Iranian Center of Neurological Research, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, IranDepartment of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran3 Department of Cardiology, Cardiovascular Diseases Research Center, Heshmat Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, IranDepartment of Virology, Pasteur Institute of Iran, Tehran, IranDepartment of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran Due to inconclusive findings of previous researches, we aimed to evaluate inflammatory state biomarkers in episodic and chronic migraineurs (EM and CM patients) compared to headache-free controls in the current study. Seventy-one migraine patients and 19 age-sex-matched controls were recruited. After obtaining demographic data and recording headache characteristics, blood samples were gathered and analyzed to evaluate the serum levels of C-reactive protein (CRP), tumor necrosis factor(TNF)-α and interleukin (IL)-6. Serum levels of IL-6, CRP and TNF-α were significantly higher among subjects with CM than the EM and controls. Further, positive correlations were noted for number of headache days/month and serum IL-6 (r=0.53, p<0.001), CRP (r=0.62, p<0.001), and TNF-α (r=0.58, p<0.001). In sum, according to current findings, a pro-inflammatory state was detected among chronic and episodic migraineurs compared to healthy control, as revealed by augmented concentrations of pro-inflammatory cytokines (e.g. IL6, CRP, and TNF-α). It was also underlined that with increasing levels of inflammatory factors, headaches tended to be more chronic. However, in order to confirm the hypothesis that neuroinflammation plays a role in migraine pain genesis, long-term cohort studies and well-designed experimental and randomized controlled trials are required. https://ijaai.tums.ac.ir/index.php/ijaai/article/view/2448HeadacheInflammatory cytokinesMigraineNeuroinflammation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mansoureh Togha Soodeh Razeghi Jahromi Zeinab Ghorbani Amir Ghaemi Pegah Rafiee |
spellingShingle |
Mansoureh Togha Soodeh Razeghi Jahromi Zeinab Ghorbani Amir Ghaemi Pegah Rafiee Evaluation of Inflammatory State in Migraineurs: A Case-control Study Iranian Journal of Allergy, Asthma and Immunology Headache Inflammatory cytokines Migraine Neuroinflammation |
author_facet |
Mansoureh Togha Soodeh Razeghi Jahromi Zeinab Ghorbani Amir Ghaemi Pegah Rafiee |
author_sort |
Mansoureh Togha |
title |
Evaluation of Inflammatory State in Migraineurs: A Case-control Study |
title_short |
Evaluation of Inflammatory State in Migraineurs: A Case-control Study |
title_full |
Evaluation of Inflammatory State in Migraineurs: A Case-control Study |
title_fullStr |
Evaluation of Inflammatory State in Migraineurs: A Case-control Study |
title_full_unstemmed |
Evaluation of Inflammatory State in Migraineurs: A Case-control Study |
title_sort |
evaluation of inflammatory state in migraineurs: a case-control study |
publisher |
Tehran University of Medical Sciences |
series |
Iranian Journal of Allergy, Asthma and Immunology |
issn |
1735-1502 1735-5249 |
publishDate |
2020-05-01 |
description |
Due to inconclusive findings of previous researches, we aimed to evaluate inflammatory state biomarkers in episodic and chronic migraineurs (EM and CM patients) compared to headache-free controls in the current study.
Seventy-one migraine patients and 19 age-sex-matched controls were recruited. After obtaining demographic data and recording headache characteristics, blood samples were gathered and analyzed to evaluate the serum levels of C-reactive protein (CRP), tumor necrosis factor(TNF)-α and interleukin (IL)-6.
Serum levels of IL-6, CRP and TNF-α were significantly higher among subjects with CM than the EM and controls. Further, positive correlations were noted for number of headache days/month and serum IL-6 (r=0.53, p<0.001), CRP (r=0.62, p<0.001), and TNF-α (r=0.58, p<0.001).
In sum, according to current findings, a pro-inflammatory state was detected among chronic and episodic migraineurs compared to healthy control, as revealed by augmented concentrations of pro-inflammatory cytokines (e.g. IL6, CRP, and TNF-α). It was also underlined that with increasing levels of inflammatory factors, headaches tended to be more chronic. However, in order to confirm the hypothesis that neuroinflammation plays a role in migraine pain genesis, long-term cohort studies and well-designed experimental and randomized controlled trials are required.
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topic |
Headache Inflammatory cytokines Migraine Neuroinflammation |
url |
https://ijaai.tums.ac.ir/index.php/ijaai/article/view/2448 |
work_keys_str_mv |
AT mansourehtogha evaluationofinflammatorystateinmigraineursacasecontrolstudy AT soodehrazeghijahromi evaluationofinflammatorystateinmigraineursacasecontrolstudy AT zeinabghorbani evaluationofinflammatorystateinmigraineursacasecontrolstudy AT amirghaemi evaluationofinflammatorystateinmigraineursacasecontrolstudy AT pegahrafiee evaluationofinflammatorystateinmigraineursacasecontrolstudy |
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