CD200 -dependent and -independent immune-modulatory functions of neural stem cells
Neural stem/precursor cells (NPC) exhibit powerful immune-modulatory properties. Attenuation of neuroinflammation by intra-cerebroventricular transplantation of NPC, protects from immune-mediated demyelination and axonal injury. The immune modulatory properties of NPC are mediated by a non-species-s...
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doaj-ea20143456b14fffb2689376133f7bc12021-10-11T04:15:41ZengElsevierStem Cell Research1873-50612021-10-0156102559CD200 -dependent and -independent immune-modulatory functions of neural stem cellsTal Arad0Nina Fainstein1Smadar Goldfarb2Marva Lachish3Tal Ganz4Tamir Ben-Hur5Department of Neurology, The Agnes Ginges Center for Human Neurogenetics, Hadassah – Hebrew University Medical Center, Jerusalem, IsraelDepartment of Neurology, The Agnes Ginges Center for Human Neurogenetics, Hadassah – Hebrew University Medical Center, Jerusalem, IsraelDepartment of Neurology, The Agnes Ginges Center for Human Neurogenetics, Hadassah – Hebrew University Medical Center, Jerusalem, IsraelDepartment of Neurology, The Agnes Ginges Center for Human Neurogenetics, Hadassah – Hebrew University Medical Center, Jerusalem, IsraelDepartment of Neurology, The Agnes Ginges Center for Human Neurogenetics, Hadassah – Hebrew University Medical Center, Jerusalem, IsraelCorresponding author.; Department of Neurology, The Agnes Ginges Center for Human Neurogenetics, Hadassah – Hebrew University Medical Center, Jerusalem, IsraelNeural stem/precursor cells (NPC) exhibit powerful immune-modulatory properties. Attenuation of neuroinflammation by intra-cerebroventricular transplantation of NPC, protects from immune-mediated demyelination and axonal injury. The immune modulatory properties of NPC are mediated by a non-species-specific, multiple bystander effect, mediated by both direct cell-cell contact, and by soluble factor(s). CD200 is a cell-surface molecule, with important roles in regulating diverse immune responses, and shown also to limit neuroinflammatory processes. We hypothesized that CD200 may play a role in mediating immune-modulatory effects of NPC.We used wild type and CD200-deficient NPC to examine the role of CD200 in mediating two vital aspects of NPC -immune modulatory properties: (1) Attenuation of autoimmune neuroinflammation; and (2) Suppression of immune rejection response towards transplanted allogeneic NPC from the host CNS.We found that CD200 is dispensable for attenuating acute experimental autoimmune neuroinflammation, but is required for protecting transplanted allogeneic NPC from immune rejection by the host tissue. CD200 deficient NPC showed similar growth, differentiation and survival properties as wild type NPC. CD200-deficient NPC attenuated efficiently T cell activation and proliferation, but exhibited reduced ability to inhibit macrophages. We conclude that CD200 plays a partial role in mediating the immune-modulatory properties of NPC. The differential effect on T cells versus macrophages may underlie the observed discrepancy in their function in vivo.http://www.sciencedirect.com/science/article/pii/S1873506121004062NPCEAECD200 and immunomodulation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Tal Arad Nina Fainstein Smadar Goldfarb Marva Lachish Tal Ganz Tamir Ben-Hur |
spellingShingle |
Tal Arad Nina Fainstein Smadar Goldfarb Marva Lachish Tal Ganz Tamir Ben-Hur CD200 -dependent and -independent immune-modulatory functions of neural stem cells Stem Cell Research NPC EAE CD200 and immunomodulation |
author_facet |
Tal Arad Nina Fainstein Smadar Goldfarb Marva Lachish Tal Ganz Tamir Ben-Hur |
author_sort |
Tal Arad |
title |
CD200 -dependent and -independent immune-modulatory functions of neural stem cells |
title_short |
CD200 -dependent and -independent immune-modulatory functions of neural stem cells |
title_full |
CD200 -dependent and -independent immune-modulatory functions of neural stem cells |
title_fullStr |
CD200 -dependent and -independent immune-modulatory functions of neural stem cells |
title_full_unstemmed |
CD200 -dependent and -independent immune-modulatory functions of neural stem cells |
title_sort |
cd200 -dependent and -independent immune-modulatory functions of neural stem cells |
publisher |
Elsevier |
series |
Stem Cell Research |
issn |
1873-5061 |
publishDate |
2021-10-01 |
description |
Neural stem/precursor cells (NPC) exhibit powerful immune-modulatory properties. Attenuation of neuroinflammation by intra-cerebroventricular transplantation of NPC, protects from immune-mediated demyelination and axonal injury. The immune modulatory properties of NPC are mediated by a non-species-specific, multiple bystander effect, mediated by both direct cell-cell contact, and by soluble factor(s). CD200 is a cell-surface molecule, with important roles in regulating diverse immune responses, and shown also to limit neuroinflammatory processes. We hypothesized that CD200 may play a role in mediating immune-modulatory effects of NPC.We used wild type and CD200-deficient NPC to examine the role of CD200 in mediating two vital aspects of NPC -immune modulatory properties: (1) Attenuation of autoimmune neuroinflammation; and (2) Suppression of immune rejection response towards transplanted allogeneic NPC from the host CNS.We found that CD200 is dispensable for attenuating acute experimental autoimmune neuroinflammation, but is required for protecting transplanted allogeneic NPC from immune rejection by the host tissue. CD200 deficient NPC showed similar growth, differentiation and survival properties as wild type NPC. CD200-deficient NPC attenuated efficiently T cell activation and proliferation, but exhibited reduced ability to inhibit macrophages. We conclude that CD200 plays a partial role in mediating the immune-modulatory properties of NPC. The differential effect on T cells versus macrophages may underlie the observed discrepancy in their function in vivo. |
topic |
NPC EAE CD200 and immunomodulation |
url |
http://www.sciencedirect.com/science/article/pii/S1873506121004062 |
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