Gamma Irradiated <i>Rhodiola sachalinensis</i> Extract Ameliorates Testosterone-Induced Benign Prostatic Hyperplasia by Downregulating 5-Alpha Reductase and Restoring Testosterone in Rats
The effect of <i>Rhodiola sachalinensis</i> Boriss extract irradiated with 50 kGy gamma rays (HKC) on benign prostatic hyperplasia (BPH) was investigated. Seven-week-old male SD rats received a subcutaneous injection of 20 mg/kg of testosterone propionate (TP) to induce BPH. Then, the te...
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doaj-ea256a3fdd8645e2bbebc3bb760aca1e2020-11-25T02:23:07ZengMDPI AGMolecules1420-30492019-11-012421398110.3390/molecules24213981molecules24213981Gamma Irradiated <i>Rhodiola sachalinensis</i> Extract Ameliorates Testosterone-Induced Benign Prostatic Hyperplasia by Downregulating 5-Alpha Reductase and Restoring Testosterone in RatsQi Xin0Mi-Jin Kwon1Ju-Woon Lee2Kwan-Soo Kim3Hao Chen4Maria G. Campos5Rosa Tundis6Cheng-Bi Cui7Young Ho Cho8Hui Cao9Key Laboratory of Changbai Mountain Biological Resources and Functional Molecular Education, Yanbian University, Yanji 133002, ChinaDivision of Efficiency Evaluation of Biomolecules, PSA Co., Ltd., Daejeon 35365, KoreaDivision of Efficiency Evaluation of Biomolecules, PSA Co., Ltd., Daejeon 35365, KoreaGreenpia Technology Inc., Yeoju-si 12619, Gyeonggi-do, KoreaSuite 18B Sea View Plaza, 18 Tai Zi Road Shekou, Shenzhen 518067, ChinaObservatory of Herb-Drug Interactions, Faculty of Pharmacy, University of Coimbra, Heath Sciences Campus, Azinhaga de Santa Comba, 3000-370 Coimbra, PortugalDepartment of Pharmacy, Health and Nutritional Sciences, University of Calabria, Via P. Bucci, 87036 Rende, ItalyKey Laboratory of Changbai Mountain Biological Resources and Functional Molecular Education, Yanbian University, Yanji 133002, ChinaDepartment of Pharmaceutics and Biotechnology, Konyang University, Daejeon 35365, KoreaGuangdong-Macau Traditional Chinese Medicine Technology Industrial Park Development Co., Ltd., Hengqin New Area, Zhuhai 519031, ChinaThe effect of <i>Rhodiola sachalinensis</i> Boriss extract irradiated with 50 kGy gamma rays (HKC) on benign prostatic hyperplasia (BPH) was investigated. Seven-week-old male SD rats received a subcutaneous injection of 20 mg/kg of testosterone propionate (TP) to induce BPH. Then, the testosterone only group received testosterone, the testosterone + finasteride group received testosterone and finasteride (5 mg/kg), the testosterone + HKC group received testosterone and HKC extract (500 mg/kg). Prostate weight and the dihydrotestosterone (DHT) levels in serum or prostate tissue were determined. The mRNA expressions of 5-alpha reductase (AR) in prostate tissue were also measured. Compared to the control group, prostate weight was significantly improved in the TP group and decreased in the HKC and finasteride-treated groups. Furthermore, the mRNA expression of 5-AR in the prostate was significantly reduced in the HKC and finasteride-treated groups. Similarly, the expression levels of α-smooth muscle actin (α-SMA) and cytokeratin, which are associated with prostatic enlargement in the HKC and finasteride groups, were much lower than in the TP group. HKC treatment showed similar efficacy to finasteride treatment on rats with testosterone-induced BPH. HKC may be explored as a potential new drug for BPH treatment.https://www.mdpi.com/1420-3049/24/21/3981<i>rhodiola sachalinensis</i>testosteronebenign prostatic hyperplasia5-alpha reductase |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Qi Xin Mi-Jin Kwon Ju-Woon Lee Kwan-Soo Kim Hao Chen Maria G. Campos Rosa Tundis Cheng-Bi Cui Young Ho Cho Hui Cao |
spellingShingle |
Qi Xin Mi-Jin Kwon Ju-Woon Lee Kwan-Soo Kim Hao Chen Maria G. Campos Rosa Tundis Cheng-Bi Cui Young Ho Cho Hui Cao Gamma Irradiated <i>Rhodiola sachalinensis</i> Extract Ameliorates Testosterone-Induced Benign Prostatic Hyperplasia by Downregulating 5-Alpha Reductase and Restoring Testosterone in Rats Molecules <i>rhodiola sachalinensis</i> testosterone benign prostatic hyperplasia 5-alpha reductase |
author_facet |
Qi Xin Mi-Jin Kwon Ju-Woon Lee Kwan-Soo Kim Hao Chen Maria G. Campos Rosa Tundis Cheng-Bi Cui Young Ho Cho Hui Cao |
author_sort |
Qi Xin |
title |
Gamma Irradiated <i>Rhodiola sachalinensis</i> Extract Ameliorates Testosterone-Induced Benign Prostatic Hyperplasia by Downregulating 5-Alpha Reductase and Restoring Testosterone in Rats |
title_short |
Gamma Irradiated <i>Rhodiola sachalinensis</i> Extract Ameliorates Testosterone-Induced Benign Prostatic Hyperplasia by Downregulating 5-Alpha Reductase and Restoring Testosterone in Rats |
title_full |
Gamma Irradiated <i>Rhodiola sachalinensis</i> Extract Ameliorates Testosterone-Induced Benign Prostatic Hyperplasia by Downregulating 5-Alpha Reductase and Restoring Testosterone in Rats |
title_fullStr |
Gamma Irradiated <i>Rhodiola sachalinensis</i> Extract Ameliorates Testosterone-Induced Benign Prostatic Hyperplasia by Downregulating 5-Alpha Reductase and Restoring Testosterone in Rats |
title_full_unstemmed |
Gamma Irradiated <i>Rhodiola sachalinensis</i> Extract Ameliorates Testosterone-Induced Benign Prostatic Hyperplasia by Downregulating 5-Alpha Reductase and Restoring Testosterone in Rats |
title_sort |
gamma irradiated <i>rhodiola sachalinensis</i> extract ameliorates testosterone-induced benign prostatic hyperplasia by downregulating 5-alpha reductase and restoring testosterone in rats |
publisher |
MDPI AG |
series |
Molecules |
issn |
1420-3049 |
publishDate |
2019-11-01 |
description |
The effect of <i>Rhodiola sachalinensis</i> Boriss extract irradiated with 50 kGy gamma rays (HKC) on benign prostatic hyperplasia (BPH) was investigated. Seven-week-old male SD rats received a subcutaneous injection of 20 mg/kg of testosterone propionate (TP) to induce BPH. Then, the testosterone only group received testosterone, the testosterone + finasteride group received testosterone and finasteride (5 mg/kg), the testosterone + HKC group received testosterone and HKC extract (500 mg/kg). Prostate weight and the dihydrotestosterone (DHT) levels in serum or prostate tissue were determined. The mRNA expressions of 5-alpha reductase (AR) in prostate tissue were also measured. Compared to the control group, prostate weight was significantly improved in the TP group and decreased in the HKC and finasteride-treated groups. Furthermore, the mRNA expression of 5-AR in the prostate was significantly reduced in the HKC and finasteride-treated groups. Similarly, the expression levels of α-smooth muscle actin (α-SMA) and cytokeratin, which are associated with prostatic enlargement in the HKC and finasteride groups, were much lower than in the TP group. HKC treatment showed similar efficacy to finasteride treatment on rats with testosterone-induced BPH. HKC may be explored as a potential new drug for BPH treatment. |
topic |
<i>rhodiola sachalinensis</i> testosterone benign prostatic hyperplasia 5-alpha reductase |
url |
https://www.mdpi.com/1420-3049/24/21/3981 |
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