Effect of intravitreal injection of anti VEGF drugs on BCVA and mfERG before and after treatment for MCNV and ICNV

AIM: To study the effect of intravitreal injection of anti- vascular endothelial growth factor(VEGF)on best corrected visual acuity(BCVA)and multifocal-electroretinogram(mfERG)before and after treatment for choroidal neovascular disease.<p>METHODS: A total of 264 patients(332 eyes)with macular...

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Main Authors: Lei Sun, Yong Tao
Format: Article
Language:English
Published: Press of International Journal of Ophthalmology (IJO PRESS) 2017-07-01
Series:Guoji Yanke Zazhi
Subjects:
Online Access:http://ies.ijo.cn/cn_publish/2017/7/201707011.pdf
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spelling doaj-ea2ab8cdb9904ba78adcd523938ce8e12020-11-24T22:55:08ZengPress of International Journal of Ophthalmology (IJO PRESS)Guoji Yanke Zazhi1672-51231672-51232017-07-011771245124810.3980/j.issn.1672-5123.2017.7.11Effect of intravitreal injection of anti VEGF drugs on BCVA and mfERG before and after treatment for MCNV and ICNVLei Sun0Yong Tao1Department of Ophthalmology, the Yellow River Central Hospital of the Yellow River Water Resources Commission, Zhengzhou 450000, Henan Province, ChinaDepartment of Ophthalmology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, ChinaAIM: To study the effect of intravitreal injection of anti- vascular endothelial growth factor(VEGF)on best corrected visual acuity(BCVA)and multifocal-electroretinogram(mfERG)before and after treatment for choroidal neovascular disease.<p>METHODS: A total of 264 patients(332 eyes)with macular neovascularization(MCNV)and idiopathic choroidal neovascular disease(ICNV)who underwent pathologic myopia from January 2015 to January 2017 were enrolled in this study. Intraocular pressure and BCVA, fundus using 90D front mirror and slit lamp detection, and the fundus photograph, OCT, ICGA and FFA angiography, mfERG detection were taken. One month after the drug, 1mo after the final treatment, we recorded BCVA, intraocular pressure and mfERG and so on. <p>RESULTS: Ranibizumab was injected into the 254 eyes, and 78 eyes were injected with conbercept. There were 37 eyes injected once, 147 eyes were injected twice, 72 eyes were injected 3 times, 57 eyes were injected 4 times, 19 eyes 5 times. There were no significant differences on intraocular pressure between the two groups(<i>P</i>>0.05). The BCVA before treatment was significantly different compared with those 1mo after treatment and 1mo after the final treatment(<i>P</i>>0.05). The amplitude of Ring1, Ring2 and Ring4 increased after treatment, the difference was statistically significant.(<i>P</i><0.05). The amplitude of Ring3 and Ring5 increased at 1mo after final treatment(<i>P</i><0.05).<p>CONCLUSION:Intravitreal injection of anti-VEGF drugs has a significant effect on BCVA and mf ERG in patients with choroidal neovascular disease and is safe.http://ies.ijo.cn/cn_publish/2017/7/201707011.pdfchoroidal neovascular diseasebest corrected visual acuitymultifocal electroretinogrammultifocal electroretinogram
collection DOAJ
language English
format Article
sources DOAJ
author Lei Sun
Yong Tao
spellingShingle Lei Sun
Yong Tao
Effect of intravitreal injection of anti VEGF drugs on BCVA and mfERG before and after treatment for MCNV and ICNV
Guoji Yanke Zazhi
choroidal neovascular disease
best corrected visual acuity
multifocal electroretinogram
multifocal electroretinogram
author_facet Lei Sun
Yong Tao
author_sort Lei Sun
title Effect of intravitreal injection of anti VEGF drugs on BCVA and mfERG before and after treatment for MCNV and ICNV
title_short Effect of intravitreal injection of anti VEGF drugs on BCVA and mfERG before and after treatment for MCNV and ICNV
title_full Effect of intravitreal injection of anti VEGF drugs on BCVA and mfERG before and after treatment for MCNV and ICNV
title_fullStr Effect of intravitreal injection of anti VEGF drugs on BCVA and mfERG before and after treatment for MCNV and ICNV
title_full_unstemmed Effect of intravitreal injection of anti VEGF drugs on BCVA and mfERG before and after treatment for MCNV and ICNV
title_sort effect of intravitreal injection of anti vegf drugs on bcva and mferg before and after treatment for mcnv and icnv
publisher Press of International Journal of Ophthalmology (IJO PRESS)
series Guoji Yanke Zazhi
issn 1672-5123
1672-5123
publishDate 2017-07-01
description AIM: To study the effect of intravitreal injection of anti- vascular endothelial growth factor(VEGF)on best corrected visual acuity(BCVA)and multifocal-electroretinogram(mfERG)before and after treatment for choroidal neovascular disease.<p>METHODS: A total of 264 patients(332 eyes)with macular neovascularization(MCNV)and idiopathic choroidal neovascular disease(ICNV)who underwent pathologic myopia from January 2015 to January 2017 were enrolled in this study. Intraocular pressure and BCVA, fundus using 90D front mirror and slit lamp detection, and the fundus photograph, OCT, ICGA and FFA angiography, mfERG detection were taken. One month after the drug, 1mo after the final treatment, we recorded BCVA, intraocular pressure and mfERG and so on. <p>RESULTS: Ranibizumab was injected into the 254 eyes, and 78 eyes were injected with conbercept. There were 37 eyes injected once, 147 eyes were injected twice, 72 eyes were injected 3 times, 57 eyes were injected 4 times, 19 eyes 5 times. There were no significant differences on intraocular pressure between the two groups(<i>P</i>>0.05). The BCVA before treatment was significantly different compared with those 1mo after treatment and 1mo after the final treatment(<i>P</i>>0.05). The amplitude of Ring1, Ring2 and Ring4 increased after treatment, the difference was statistically significant.(<i>P</i><0.05). The amplitude of Ring3 and Ring5 increased at 1mo after final treatment(<i>P</i><0.05).<p>CONCLUSION:Intravitreal injection of anti-VEGF drugs has a significant effect on BCVA and mf ERG in patients with choroidal neovascular disease and is safe.
topic choroidal neovascular disease
best corrected visual acuity
multifocal electroretinogram
multifocal electroretinogram
url http://ies.ijo.cn/cn_publish/2017/7/201707011.pdf
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