Morcellation-Induced Leiomyomatosis Peritonealis Disseminata: A Rare Case Report
Leiomyomatosis peritonealis disseminata (LPD) is a benign disease characterized by the presence of multiple small nodules on the omentum, parietal, and visceral peritoneum. It corresponds to leiomyoma and often resembles metastases of malignant tumors; however, with favorable prognosis. Here we desc...
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doaj-ea2d1fd88513487ba186ea6b37653bed2020-11-25T01:47:12ZengShiraz University of Medical SciencesIranian Journal of Medical Sciences0253-07161735-36882019-01-01441606410.30476/ijms.2019.4061440614Morcellation-Induced Leiomyomatosis Peritonealis Disseminata: A Rare Case ReportAlina Vitalievna Gerashchenko0Tatyana Grygorievna Filonenko1Elena Petrovna Golubinskaya2Margarita Alexeevna Kalfa3Maxim Andreevich Kriventsov4Department of Pathological Anatomy, Faculty of Medicine, Medical Academy Named After S.I. Georgievsky, V.I. Vernadsky Crimean Federal University, Simferopol, RussiaDepartment of Pathological Anatomy, Faculty of Medicine, Medical Academy Named After S.I. Georgievsky, V.I. Vernadsky Crimean Federal University, Simferopol, RussiaDepartment of Pathological Anatomy, Faculty of Medicine, Medical Academy Named After S.I. Georgievsky, V.I. Vernadsky Crimean Federal University, Simferopol, RussiaDepartment of Pathological Anatomy, Faculty of Medicine, Medical Academy Named After S.I. Georgievsky, V.I. Vernadsky Crimean Federal University, Simferopol, RussiaDepartment of Pathological Anatomy, Faculty of Medicine, Medical Academy Named After S.I. Georgievsky, V.I. Vernadsky Crimean Federal University, Simferopol, RussiaLeiomyomatosis peritonealis disseminata (LPD) is a benign disease characterized by the presence of multiple small nodules on the omentum, parietal, and visceral peritoneum. It corresponds to leiomyoma and often resembles metastases of malignant tumors; however, with favorable prognosis. Here we describe a 46-year-old woman, diagnosed with LPD, to demonstrate the etiopathogenesis of the developed leiomyomatosis following endoscopic extirpation of the uterus with the use of a power morcellator. The patient was operated for diffuse leiomyoma using a power morcellator. Six months later, during a follow-up visit, disseminated tumor nodes on the peritoneum were revealed. Histological and immunohistochemical (smooth muscle α-actin, vimentin, estrogen receptors, progesterone receptors, and Ki67) study confirmed the diagnosis of LPD. As part of the follow-up, certain regression of the tumor nodes was noted against the backdrop of the onset of menopause and the corresponding decline of estrogen levels. Currently, the prognosis is favorable and follow-up is ongoing. Such cases are rare, but the condition is particularly important due to its iatrogenic nature. It has attracted the attention of the Food and Drug Administration (FDA) because power morcellation is probably associated with the risk of spreading suspected cancerous tissue. The existing high risk of iatrogenic LPD formation indicates the need for detailed reporting of all similar clinical cases, including the established pathogenetic and pathomorphological mechanisms of this process to prevent morcellator-related complications.http://ijms.sums.ac.ir/article_40614_e82419193fdac9961ff2faae3c1c5f37.pdfLeiomyomatosisPeritoneumIatrogenic disease |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Alina Vitalievna Gerashchenko Tatyana Grygorievna Filonenko Elena Petrovna Golubinskaya Margarita Alexeevna Kalfa Maxim Andreevich Kriventsov |
spellingShingle |
Alina Vitalievna Gerashchenko Tatyana Grygorievna Filonenko Elena Petrovna Golubinskaya Margarita Alexeevna Kalfa Maxim Andreevich Kriventsov Morcellation-Induced Leiomyomatosis Peritonealis Disseminata: A Rare Case Report Iranian Journal of Medical Sciences Leiomyomatosis Peritoneum Iatrogenic disease |
author_facet |
Alina Vitalievna Gerashchenko Tatyana Grygorievna Filonenko Elena Petrovna Golubinskaya Margarita Alexeevna Kalfa Maxim Andreevich Kriventsov |
author_sort |
Alina Vitalievna Gerashchenko |
title |
Morcellation-Induced Leiomyomatosis Peritonealis Disseminata: A Rare Case Report |
title_short |
Morcellation-Induced Leiomyomatosis Peritonealis Disseminata: A Rare Case Report |
title_full |
Morcellation-Induced Leiomyomatosis Peritonealis Disseminata: A Rare Case Report |
title_fullStr |
Morcellation-Induced Leiomyomatosis Peritonealis Disseminata: A Rare Case Report |
title_full_unstemmed |
Morcellation-Induced Leiomyomatosis Peritonealis Disseminata: A Rare Case Report |
title_sort |
morcellation-induced leiomyomatosis peritonealis disseminata: a rare case report |
publisher |
Shiraz University of Medical Sciences |
series |
Iranian Journal of Medical Sciences |
issn |
0253-0716 1735-3688 |
publishDate |
2019-01-01 |
description |
Leiomyomatosis peritonealis disseminata (LPD) is a benign disease characterized by the presence of multiple small nodules on the omentum, parietal, and visceral peritoneum. It corresponds to leiomyoma and often resembles metastases of malignant tumors; however, with favorable prognosis. Here we describe a 46-year-old woman, diagnosed with LPD, to demonstrate the etiopathogenesis of the developed leiomyomatosis following endoscopic extirpation of the uterus with the use of a power morcellator. The patient was operated for diffuse leiomyoma using a power morcellator. Six months later, during a follow-up visit, disseminated tumor nodes on the peritoneum were revealed. Histological and immunohistochemical (smooth muscle α-actin, vimentin, estrogen receptors, progesterone receptors, and Ki67) study confirmed the diagnosis of LPD. As part of the follow-up, certain regression of the tumor nodes was noted against the backdrop of the onset of menopause and the corresponding decline of estrogen levels. Currently, the prognosis is favorable and follow-up is ongoing. Such cases are rare, but the condition is particularly important due to its iatrogenic nature. It has attracted the attention of the Food and Drug Administration (FDA) because power morcellation is probably associated with the risk of spreading suspected cancerous tissue. The existing high risk of iatrogenic LPD formation indicates the need for detailed reporting of all similar clinical cases, including the established pathogenetic and pathomorphological mechanisms of this process to prevent morcellator-related complications. |
topic |
Leiomyomatosis Peritoneum Iatrogenic disease |
url |
http://ijms.sums.ac.ir/article_40614_e82419193fdac9961ff2faae3c1c5f37.pdf |
work_keys_str_mv |
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