Single-Cell Gene Expression Analysis of a Human ESC Model of Pancreatic Endocrine Development Reveals Different Paths to β-Cell Differentiation

Single-Cell Gene Expression Analysis of a Human ESC Model of Pancreatic Endocrine Development Reveals Different Paths to β-Cell Differentiation

The production of insulin-producing β cells from human embryonic stem cells (hESCs) in vitro represents a promising strategy for a cell-based therapy for type 1 diabetes mellitus. To explore the cellular heterogeneity and temporal progression of endocrine progenitors and their progeny, we performed...

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Bibliographic Details
Main Authors: Maja Borup Kjær Petersen, Ajuna Azad, Camilla Ingvorsen, Katja Hess, Mattias Hansson, Anne Grapin-Botton, Christian Honoré
Format: Article
Language:English
Published: Elsevier 2017-10-01
Series:Stem Cell Reports
Subjects:
endocrine
pancreas
progenitor
differentiation
hormone
lineage
NEUROG3
pluripotent stem cells
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671117303661

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