Does Thyroid dysfunction correlates with iron overload in Eβ thalassemia patients? A study from a tertiary care thalassemia center in India
Background and Aim: Large number of Haemoglobin E-beta thalassaemia (Hb E/β-thalassaemia) patients show iron overloads and related end-organ damage irrespective of transfusion requirements. The prevalence of hypothyroidism in Indian population is approximately 11%. We studied the relationship betwee...
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doaj-ea31d82f198a4987a149bde0c989d1d72020-11-25T01:54:26ZengWolters Kluwer Medknow PublicationsArchives of Medicine and Health Sciences2321-48482019-01-017220621110.4103/amhs.amhs_61_19Does Thyroid dysfunction correlates with iron overload in Eβ thalassemia patients? A study from a tertiary care thalassemia center in IndiaShuvraneel BaulTuphan Kanti DolaiPranab Kumar SahanaRajib DePrakas Kumar MandalPrantar ChakrabartiBackground and Aim: Large number of Haemoglobin E-beta thalassaemia (Hb E/β-thalassaemia) patients show iron overloads and related end-organ damage irrespective of transfusion requirements. The prevalence of hypothyroidism in Indian population is approximately 11%. We studied the relationship between thyroid dysfunction and iron overload in Hb E/β-thalassaemia. Materials and Methods: The study included Eβ-thalassemia patients above the age of 10 years. Patient's serum ferritin level evaluated for the evaluation of iron status and thyroid-stimulating hormone, FT4, T3 for thyroid function status. Results: The study was conducted from January 2016 to December 2017. Of 50 Eβ-thalassemia patients, there were 22 females; the mean age was 19 years (range: 12–47 years). A total of 22 (44%) patients showed thyroid dysfunction; overt hypothyroidism seen in 6 (12%) patients with mean ferritin level of 1077 ng/ml and subclinical hypothyroidism seen in 16 (32%) patients with mean ferritin level of 1200 ng/ml. Normal thyroid function seen in 28 (56%) of patients with mean ferritin level of 1155 ng/ml. Conclusion: The prevalence of thyroid dysfunction was found to be higher in Hb E/β-thalassaemia patients, but a definite correlation with the serum ferritin level could not be established.http://www.amhsjournal.org/article.asp?issn=2321-4848;year=2019;volume=7;issue=2;spage=206;epage=211;aulast=Baulhb e/β-thalassaemiaserum ferritinthyroid function |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Shuvraneel Baul Tuphan Kanti Dolai Pranab Kumar Sahana Rajib De Prakas Kumar Mandal Prantar Chakrabarti |
spellingShingle |
Shuvraneel Baul Tuphan Kanti Dolai Pranab Kumar Sahana Rajib De Prakas Kumar Mandal Prantar Chakrabarti Does Thyroid dysfunction correlates with iron overload in Eβ thalassemia patients? A study from a tertiary care thalassemia center in India Archives of Medicine and Health Sciences hb e/β-thalassaemia serum ferritin thyroid function |
author_facet |
Shuvraneel Baul Tuphan Kanti Dolai Pranab Kumar Sahana Rajib De Prakas Kumar Mandal Prantar Chakrabarti |
author_sort |
Shuvraneel Baul |
title |
Does Thyroid dysfunction correlates with iron overload in Eβ thalassemia patients? A study from a tertiary care thalassemia center in India |
title_short |
Does Thyroid dysfunction correlates with iron overload in Eβ thalassemia patients? A study from a tertiary care thalassemia center in India |
title_full |
Does Thyroid dysfunction correlates with iron overload in Eβ thalassemia patients? A study from a tertiary care thalassemia center in India |
title_fullStr |
Does Thyroid dysfunction correlates with iron overload in Eβ thalassemia patients? A study from a tertiary care thalassemia center in India |
title_full_unstemmed |
Does Thyroid dysfunction correlates with iron overload in Eβ thalassemia patients? A study from a tertiary care thalassemia center in India |
title_sort |
does thyroid dysfunction correlates with iron overload in eβ thalassemia patients? a study from a tertiary care thalassemia center in india |
publisher |
Wolters Kluwer Medknow Publications |
series |
Archives of Medicine and Health Sciences |
issn |
2321-4848 |
publishDate |
2019-01-01 |
description |
Background and Aim: Large number of Haemoglobin E-beta thalassaemia (Hb E/β-thalassaemia) patients show iron overloads and related end-organ damage irrespective of transfusion requirements. The prevalence of hypothyroidism in Indian population is approximately 11%. We studied the relationship between thyroid dysfunction and iron overload in Hb E/β-thalassaemia. Materials and Methods: The study included Eβ-thalassemia patients above the age of 10 years. Patient's serum ferritin level evaluated for the evaluation of iron status and thyroid-stimulating hormone, FT4, T3 for thyroid function status. Results: The study was conducted from January 2016 to December 2017. Of 50 Eβ-thalassemia patients, there were 22 females; the mean age was 19 years (range: 12–47 years). A total of 22 (44%) patients showed thyroid dysfunction; overt hypothyroidism seen in 6 (12%) patients with mean ferritin level of 1077 ng/ml and subclinical hypothyroidism seen in 16 (32%) patients with mean ferritin level of 1200 ng/ml. Normal thyroid function seen in 28 (56%) of patients with mean ferritin level of 1155 ng/ml. Conclusion: The prevalence of thyroid dysfunction was found to be higher in Hb E/β-thalassaemia patients, but a definite correlation with the serum ferritin level could not be established. |
topic |
hb e/β-thalassaemia serum ferritin thyroid function |
url |
http://www.amhsjournal.org/article.asp?issn=2321-4848;year=2019;volume=7;issue=2;spage=206;epage=211;aulast=Baul |
work_keys_str_mv |
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