A Neurobiological Hypothesis of Treatment-Resistant Depression – Mechanisms for Selective Serotonin Reuptake Inhibitor Non-Efficacy

A Neurobiological Hypothesis of Treatment-Resistant Depression – Mechanisms for Selective Serotonin Reuptake Inhibitor Non-Efficacy

First-line treatment of major depression includes administration of a selective serotonin reuptake inhibitor (SSRI), yet studies suggest that remission rates following two trials of an SSRI are less than 50%. The authors examine the putative biological substrates underlying Treatment Refractory Depr...

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Bibliographic Details
Main Authors: Jeremy D Coplan, Srinath eGopinath, Chadi G Abdallah, Benjamin eBerry
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-05-01
Series:Frontiers in Behavioral Neuroscience
Subjects:
Hippocampus
Glutamate
Lamotrigine
dorsal raphe
selective serotonin reuptake inhibitors (SSRIs)
Treatment-Resistant Depression (TRD)
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnbeh.2014.00189/full

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