Resensitization of methicillin-resistant Staphylococcus aureus by amoxapine, an FDA-approved antidepressant
The rapid increase in bacterial resistance to antibiotics is a global healthcare crisis. Non-antibiotic pharmaceuticals that have attained approval by the United States Food and Drug Administration have the potential to be repurposed as bacterial resistance-modifying agents and therefore could becom...
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doaj-ea3fbe0995cd4b2dbcb8dd975cc69a0b2020-11-25T01:34:25ZengElsevierHeliyon2405-84402018-01-014110.1016/j.heliyon.2017.e00501Resensitization of methicillin-resistant Staphylococcus aureus by amoxapine, an FDA-approved antidepressantTyler J. Wilson0Meghan S. Blackledge1Patrick A. Vigueira2Department of Biology, High Point University, High Point, NC 27268, United StatesDepartment of Chemistry, High Point University, High Point, NC 27268, United StatesDepartment of Biology, High Point University, High Point, NC 27268, United StatesThe rapid increase in bacterial resistance to antibiotics is a global healthcare crisis. Non-antibiotic pharmaceuticals that have attained approval by the United States Food and Drug Administration have the potential to be repurposed as bacterial resistance-modifying agents and therefore could become valuable resources in our battle against antibiotic-resistant microbes. Amoxapine is a tetracyclic antidepressant used in the treatment of major depressive disorder. Here we demonstrate the ability of amoxapine to resensitize methicillin-resistant Staphylococcus aureus strain ATCC 43300 to oxacillin in both agar diffusion and broth microdilution assays. Amoxapine also reduced the bacterial cleavage of nitrocefin in a dose-dependent manner, suggesting that it may exert its adjuvant effects through reduction of beta-lactamase activity.http://www.sciencedirect.com/science/article/pii/S2405844017330049Microbiology |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Tyler J. Wilson Meghan S. Blackledge Patrick A. Vigueira |
spellingShingle |
Tyler J. Wilson Meghan S. Blackledge Patrick A. Vigueira Resensitization of methicillin-resistant Staphylococcus aureus by amoxapine, an FDA-approved antidepressant Heliyon Microbiology |
author_facet |
Tyler J. Wilson Meghan S. Blackledge Patrick A. Vigueira |
author_sort |
Tyler J. Wilson |
title |
Resensitization of methicillin-resistant Staphylococcus aureus by amoxapine, an FDA-approved antidepressant |
title_short |
Resensitization of methicillin-resistant Staphylococcus aureus by amoxapine, an FDA-approved antidepressant |
title_full |
Resensitization of methicillin-resistant Staphylococcus aureus by amoxapine, an FDA-approved antidepressant |
title_fullStr |
Resensitization of methicillin-resistant Staphylococcus aureus by amoxapine, an FDA-approved antidepressant |
title_full_unstemmed |
Resensitization of methicillin-resistant Staphylococcus aureus by amoxapine, an FDA-approved antidepressant |
title_sort |
resensitization of methicillin-resistant staphylococcus aureus by amoxapine, an fda-approved antidepressant |
publisher |
Elsevier |
series |
Heliyon |
issn |
2405-8440 |
publishDate |
2018-01-01 |
description |
The rapid increase in bacterial resistance to antibiotics is a global healthcare crisis. Non-antibiotic pharmaceuticals that have attained approval by the United States Food and Drug Administration have the potential to be repurposed as bacterial resistance-modifying agents and therefore could become valuable resources in our battle against antibiotic-resistant microbes. Amoxapine is a tetracyclic antidepressant used in the treatment of major depressive disorder. Here we demonstrate the ability of amoxapine to resensitize methicillin-resistant Staphylococcus aureus strain ATCC 43300 to oxacillin in both agar diffusion and broth microdilution assays. Amoxapine also reduced the bacterial cleavage of nitrocefin in a dose-dependent manner, suggesting that it may exert its adjuvant effects through reduction of beta-lactamase activity. |
topic |
Microbiology |
url |
http://www.sciencedirect.com/science/article/pii/S2405844017330049 |
work_keys_str_mv |
AT tylerjwilson resensitizationofmethicillinresistantstaphylococcusaureusbyamoxapineanfdaapprovedantidepressant AT meghansblackledge resensitizationofmethicillinresistantstaphylococcusaureusbyamoxapineanfdaapprovedantidepressant AT patrickavigueira resensitizationofmethicillinresistantstaphylococcusaureusbyamoxapineanfdaapprovedantidepressant |
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