Beaver and Naked Mole Rat Genomes Reveal Common Paths to Longevity
Summary: Long-lived rodents have become an attractive model for the studies on aging. To understand evolutionary paths to long life, we prepare chromosome-level genome assemblies of the two longest-lived rodents, Canadian beaver (Castor canadensis) and naked mole rat (NMR, Heterocephalus glaber), wh...
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doaj-ea51d19aa12e402fac6d66e05cd4f5252020-11-25T03:30:32ZengElsevierCell Reports2211-12472020-07-01324107949Beaver and Naked Mole Rat Genomes Reveal Common Paths to LongevityXuming Zhou0Qianhui Dou1Guangyi Fan2Quanwei Zhang3Maxwell Sanderford4Alaattin Kaya5Jeremy Johnson6Elinor K. Karlsson7Xiao Tian8Aleksei Mikhalchenko9Sudhir Kumar10Andrei Seluanov11Zhengdong D. Zhang12Vera Gorbunova13Xin Liu14Vadim N. Gladyshev15Division of Genetics, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of Harvard and MIT, Cambridge, Massachusetts, MA 02142, USADivision of Genetics, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USABGI—Shenzhen, Shenzhen 518083, ChinaAlbert Einstein College of Medicine, Bronx, NY 10461, USAInstitute for Genomics and Evolutionary Medicine, Temple University, Philadelphia, PA 19122, USADivision of Genetics, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of Harvard and MIT, Cambridge, Massachusetts, MA 02142, USA; Department of Biology, Virginia Commonwealth University, Richmond, VA 23284 USABroad Institute of Harvard and MIT, Cambridge, Massachusetts, MA 02142, USABroad Institute of Harvard and MIT, Cambridge, Massachusetts, MA 02142, USA; University of Massachusetts Medical School, Worcester, MA 01655, USADepartment of Biology, University of Rochester, Rochester, NY 14627, USA; Department of Medicine, University of Rochester, Rochester, NY 14627, USADivision of Genetics, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USAInstitute for Genomics and Evolutionary Medicine, Temple University, Philadelphia, PA 19122, USADepartment of Biology, University of Rochester, Rochester, NY 14627, USA; Department of Medicine, University of Rochester, Rochester, NY 14627, USAAlbert Einstein College of Medicine, Bronx, NY 10461, USADepartment of Biology, University of Rochester, Rochester, NY 14627, USA; Department of Medicine, University of Rochester, Rochester, NY 14627, USABGI—Shenzhen, Shenzhen 518083, ChinaDivision of Genetics, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of Harvard and MIT, Cambridge, Massachusetts, MA 02142, USA; Corresponding authorSummary: Long-lived rodents have become an attractive model for the studies on aging. To understand evolutionary paths to long life, we prepare chromosome-level genome assemblies of the two longest-lived rodents, Canadian beaver (Castor canadensis) and naked mole rat (NMR, Heterocephalus glaber), which were scaffolded with in vitro proximity ligation and chromosome conformation capture data and complemented with long-read sequencing. Our comparative genomic analyses reveal that amino acid substitutions at “disease-causing” sites are widespread in the rodent genomes and that identical substitutions in long-lived rodents are associated with common adaptive phenotypes, e.g., enhanced resistance to DNA damage and cellular stress. By employing a newly developed substitution model and likelihood ratio test, we find that energy and fatty acid metabolism pathways are enriched for signals of positive selection in both long-lived rodents. Thus, the high-quality genome resource of long-lived rodents can assist in the discovery of genetic factors that control longevity and adaptive evolution.http://www.sciencedirect.com/science/article/pii/S221112472030930Xbeavernaked mole ratgenomestress resistancelongevityaging |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Xuming Zhou Qianhui Dou Guangyi Fan Quanwei Zhang Maxwell Sanderford Alaattin Kaya Jeremy Johnson Elinor K. Karlsson Xiao Tian Aleksei Mikhalchenko Sudhir Kumar Andrei Seluanov Zhengdong D. Zhang Vera Gorbunova Xin Liu Vadim N. Gladyshev |
spellingShingle |
Xuming Zhou Qianhui Dou Guangyi Fan Quanwei Zhang Maxwell Sanderford Alaattin Kaya Jeremy Johnson Elinor K. Karlsson Xiao Tian Aleksei Mikhalchenko Sudhir Kumar Andrei Seluanov Zhengdong D. Zhang Vera Gorbunova Xin Liu Vadim N. Gladyshev Beaver and Naked Mole Rat Genomes Reveal Common Paths to Longevity Cell Reports beaver naked mole rat genome stress resistance longevity aging |
author_facet |
Xuming Zhou Qianhui Dou Guangyi Fan Quanwei Zhang Maxwell Sanderford Alaattin Kaya Jeremy Johnson Elinor K. Karlsson Xiao Tian Aleksei Mikhalchenko Sudhir Kumar Andrei Seluanov Zhengdong D. Zhang Vera Gorbunova Xin Liu Vadim N. Gladyshev |
author_sort |
Xuming Zhou |
title |
Beaver and Naked Mole Rat Genomes Reveal Common Paths to Longevity |
title_short |
Beaver and Naked Mole Rat Genomes Reveal Common Paths to Longevity |
title_full |
Beaver and Naked Mole Rat Genomes Reveal Common Paths to Longevity |
title_fullStr |
Beaver and Naked Mole Rat Genomes Reveal Common Paths to Longevity |
title_full_unstemmed |
Beaver and Naked Mole Rat Genomes Reveal Common Paths to Longevity |
title_sort |
beaver and naked mole rat genomes reveal common paths to longevity |
publisher |
Elsevier |
series |
Cell Reports |
issn |
2211-1247 |
publishDate |
2020-07-01 |
description |
Summary: Long-lived rodents have become an attractive model for the studies on aging. To understand evolutionary paths to long life, we prepare chromosome-level genome assemblies of the two longest-lived rodents, Canadian beaver (Castor canadensis) and naked mole rat (NMR, Heterocephalus glaber), which were scaffolded with in vitro proximity ligation and chromosome conformation capture data and complemented with long-read sequencing. Our comparative genomic analyses reveal that amino acid substitutions at “disease-causing” sites are widespread in the rodent genomes and that identical substitutions in long-lived rodents are associated with common adaptive phenotypes, e.g., enhanced resistance to DNA damage and cellular stress. By employing a newly developed substitution model and likelihood ratio test, we find that energy and fatty acid metabolism pathways are enriched for signals of positive selection in both long-lived rodents. Thus, the high-quality genome resource of long-lived rodents can assist in the discovery of genetic factors that control longevity and adaptive evolution. |
topic |
beaver naked mole rat genome stress resistance longevity aging |
url |
http://www.sciencedirect.com/science/article/pii/S221112472030930X |
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