Regulatory network analyses reveal genome-wide potentiation of LIF signaling by glucocorticoids and define an innate cell defense response.

Regulatory network analyses reveal genome-wide potentiation of LIF signaling by glucocorticoids and define an innate cell defense response.

While the hypothalamo-pituitary-adrenal axis (HPA) activates a general stress response by increasing glucocorticoid (Gc) synthesis, biological stress resulting from infections triggers the inflammatory response through production of cytokines. The pituitary gland integrates some of these signals by...

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Bibliographic Details
Main Authors: David Langlais, Catherine Couture, Aurélio Balsalobre, Jacques Drouin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-10-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC2562516?pdf=render

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