Caveolin-1-Mediated Tumor Suppression Is Linked to Reduced HIF1α S-Nitrosylation and Transcriptional Activity in Hypoxia

Caveolin-1-Mediated Tumor Suppression Is Linked to Reduced HIF1α S-Nitrosylation and Transcriptional Activity in Hypoxia

Caveolin-1 (CAV1) is a well-established nitric oxide synthase inhibitor, whose function as a tumor suppressor is favored by, but not entirely dependent on, the presence of E-cadherin. Tumors are frequently hypoxic and the activation of the hypoxia-inducible factor-1α (HIF1α) promotes tumor growth. H...

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Bibliographic Details
Main Authors: Carlos Sanhueza, Jimena Castillo Bennett, Manuel Valenzuela-Valderrama, Pamela Contreras, Lorena Lobos-González, América Campos, Sergio Wehinger, Álvaro Lladser, Rolf Kiessling, Lisette Leyton, Andrew F.G. Quest
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Cancers
Subjects:
caveolin-1
hypoxia
HIF1α
S-nitrosylation
tumor suppression
VEGF
Online Access:https://www.mdpi.com/2072-6694/12/9/2349

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