HIF-1 activation induces doxorubicin resistance in MCF7 3-D spheroids via P-glycoprotein expression: a potential model of the chemo-resistance of invasive micropapillary carcinoma of the breast

HIF-1 activation induces doxorubicin resistance in MCF7 3-D spheroids via P-glycoprotein expression: a potential model of the chemo-resistance of invasive micropapillary carcinoma of the breast

<p>Abstract</p> <p>Background</p> <p>Invasive micropapillary carcinoma (IMPC) of the breast is a distinct and aggressive variant of luminal type B breast cancer that does not respond to neoadjuvant chemotherapy. It is characterized by small pseudopapillary clusters of c...

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Bibliographic Details
Main Authors: Doublier Sophie, Belisario Dimas C, Polimeni Manuela, Annaratone Laura, Riganti Chiara, Allia Elena, Ghigo Dario, Bosia Amalia, Sapino Anna
Format: Article
Language:English
Published: BMC 2012-01-01
Series:BMC Cancer
Subjects:
HIF-1α
3-D spheroids, Elastase
Invasive micropapillary breast carcinoma
Doxorubicin resistance
P-glycoprotein
MUC-1
Online Access:http://www.biomedcentral.com/1471-2407/12/4

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http://www.biomedcentral.com/1471-2407/12/4

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