Advances of Application of Transgenic Mice in Models with Breast Cancer

• Main Authors: Ming-juan LI, Xiao-hong JIANG, Guang-chun GAO, Xuan HUANG
• Format: Article
• Language: English
• Published: Third Party Medicine International Publishing Group Co. Limited 2017-03-01
• Series: Journal of International Translational Medicine
• Subjects: Transgenic animal models; Breast cancer; PathogenesisFund:Science Technology Department of Zhejiang Province Projects: Establishment of Mice Models with High-Expression Human-Originated Her2 Breast Cancer (2014C37018); and Effect and Mechanisms of Polyphenol from Trapa Acornis Hull Inhibiting Angiogenesis of Mice Breast Cancer Models with High-expression Human-originated HER2(2016C37097)
• Online Access: http://www.jitm.hk/EN/abstract/abstract234.shtml

With the frequent cross fusion of medicine and molecular genetics, study on molecular aspects has become an important step in disclosing the pathogenesis of various diseases. The morbidity of breast cancer ranks the top one in malignancies in women, and is always the hot topic of researches. The establishment of transgenic animals has received more and more attentions because it can provide a more direct and effective platform to understand the pathogenesis of breast cancer as well as development of therapeutic agents. This study mainly emphasized on the application advances of transgenic animal techniques and transgenic mice in models with breast cancer.