Understanding the Reaction Crystallization Process of Glycidyl Trimethyl Ammonium Chloride

Reaction crystallization to produce glycidyl trimethyl ammonium chloride (GTA) via epichlorohydrin with gas-state trimethylamine was investigated. The crystallization process of the GTA gas-liquid reaction was optimized by a seed method. The optimized technology can prepare GTA products with crystal...

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Main Authors:	Shuai Yu, Hui Chen, Xujie Gao, Weichun Feng, Wenguo Xing, Shichao Du, Yan Wang, Fumin Xue, Yan Cheng
Format:	Article
Language:	English
Published:	MDPI AG 2021-04-01
Series:	Crystals
Subjects:	glycidyl trimethyl ammonium chloride (GTA) reaction crystallization purity crystallization process optimization
Online Access:	https://www.mdpi.com/2073-4352/11/4/449

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spelling	doaj-ea7c11d14aff4c5fa929e0a27152cc692021-04-20T23:04:08ZengMDPI AGCrystals2073-43522021-04-011144944910.3390/cryst11040449Understanding the Reaction Crystallization Process of Glycidyl Trimethyl Ammonium ChlorideShuai Yu0Hui Chen1Xujie Gao2Weichun Feng3Wenguo Xing4Shichao Du5Yan Wang6Fumin Xue7Yan Cheng8Shandong Analysis and Test Center, School of Pharmaceutical Sciences, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250014, ChinaShandong Analysis and Test Center, School of Pharmaceutical Sciences, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250014, ChinaShandong Analysis and Test Center, School of Pharmaceutical Sciences, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250014, ChinaChemical Technology Research Institute of Shandong, Qingdao University of Science & Technology, Jinan 250014, ChinaChemical Technology Research Institute of Shandong, Qingdao University of Science & Technology, Jinan 250014, ChinaShandong Analysis and Test Center, School of Pharmaceutical Sciences, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250014, ChinaShandong Analysis and Test Center, School of Pharmaceutical Sciences, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250014, ChinaShandong Analysis and Test Center, School of Pharmaceutical Sciences, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250014, ChinaShandong Analysis and Test Center, School of Pharmaceutical Sciences, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250014, ChinaReaction crystallization to produce glycidyl trimethyl ammonium chloride (GTA) via epichlorohydrin with gas-state trimethylamine was investigated. The crystallization process of the GTA gas-liquid reaction was optimized by a seed method. The optimized technology can prepare GTA products with crystal form and purity greater than 97%. The crystallization process of GTA consists of four steps (i.e., addition of seed, dispersion of seed, growth of crystals on the seed surfaces, agglomeration and growth of crystal). Seed method and flow rate are the key factors affecting purity. The purity and particle size of GTA crystals were satisfactory as long as the operation was kept within the defined envelope. The experiments were conducted on a 1 L reactor and successfully scaled-up to 3000 L in industry.https://www.mdpi.com/2073-4352/11/4/449glycidyl trimethyl ammonium chloride (GTA)reaction crystallizationpuritycrystallization process optimization
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Shuai Yu Hui Chen Xujie Gao Weichun Feng Wenguo Xing Shichao Du Yan Wang Fumin Xue Yan Cheng
spellingShingle	Shuai Yu Hui Chen Xujie Gao Weichun Feng Wenguo Xing Shichao Du Yan Wang Fumin Xue Yan Cheng Understanding the Reaction Crystallization Process of Glycidyl Trimethyl Ammonium Chloride Crystals glycidyl trimethyl ammonium chloride (GTA) reaction crystallization purity crystallization process optimization
author_facet	Shuai Yu Hui Chen Xujie Gao Weichun Feng Wenguo Xing Shichao Du Yan Wang Fumin Xue Yan Cheng
author_sort	Shuai Yu
title	Understanding the Reaction Crystallization Process of Glycidyl Trimethyl Ammonium Chloride
title_short	Understanding the Reaction Crystallization Process of Glycidyl Trimethyl Ammonium Chloride
title_full	Understanding the Reaction Crystallization Process of Glycidyl Trimethyl Ammonium Chloride
title_fullStr	Understanding the Reaction Crystallization Process of Glycidyl Trimethyl Ammonium Chloride
title_full_unstemmed	Understanding the Reaction Crystallization Process of Glycidyl Trimethyl Ammonium Chloride
title_sort	understanding the reaction crystallization process of glycidyl trimethyl ammonium chloride
publisher	MDPI AG
series	Crystals
issn	2073-4352
publishDate	2021-04-01
description	Reaction crystallization to produce glycidyl trimethyl ammonium chloride (GTA) via epichlorohydrin with gas-state trimethylamine was investigated. The crystallization process of the GTA gas-liquid reaction was optimized by a seed method. The optimized technology can prepare GTA products with crystal form and purity greater than 97%. The crystallization process of GTA consists of four steps (i.e., addition of seed, dispersion of seed, growth of crystals on the seed surfaces, agglomeration and growth of crystal). Seed method and flow rate are the key factors affecting purity. The purity and particle size of GTA crystals were satisfactory as long as the operation was kept within the defined envelope. The experiments were conducted on a 1 L reactor and successfully scaled-up to 3000 L in industry.
topic	glycidyl trimethyl ammonium chloride (GTA) reaction crystallization purity crystallization process optimization
url	https://www.mdpi.com/2073-4352/11/4/449
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Understanding the Reaction Crystallization Process of Glycidyl Trimethyl Ammonium Chloride

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