Siroheme synthase orients substrates for dehydrogenase and chelatase activities in a common active site
Siroheme is an essential bacterial iron tetrapyrrole used by siroheme-dependent sulfite and nitrite reductases. Here the authors shed light on the catalytic mechanisms of siroheme synthase through the structures of the bifunctional dehydrogenase/chelatase CysG module bound to its substrate, precorri...
Main Authors: | Joseph M. Pennington, Michael Kemp, Lauren McGarry, Yu Chen, M. Elizabeth Stroupe |
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Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2020-02-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-020-14722-1 |
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