Smad2-dependent downregulation of miR-30 is required for TGF-β-induced apoptosis in podocytes.
Transforming growth factors beta (TGF-β) are multi-functional cytokines capable of inducing apoptosis in epithelial cells, including glomerular podocytes. We and others have previously shown that podocyte-selective genetic deletion of the microRNA (miR)-processing enzyme, Dicer, caused glomeruloscle...
Main Authors: | Shaolin Shi, Liping Yu, Taoran Zhang, Haiying Qi, Sandhya Xavier, Wenjun Ju, Erwin Bottinger |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2013-01-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC3784460?pdf=render |
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