HU-671, a Novel Oleoyl Serine Derivative, Exhibits Enhanced Efficacy in Reversing Ovariectomy-Induced Osteoporosis and Bone Marrow Adiposity

HU-671, a Novel Oleoyl Serine Derivative, Exhibits Enhanced Efficacy in Reversing Ovariectomy-Induced Osteoporosis and Bone Marrow Adiposity

Oleoyl serine (OS), an endogenous fatty acyl amide (FAA) found in bone, has been shown to have an anti-osteoporotic effect. OS, being an amide, can be hydrolyzed in the body by amidases. Hindering its amide bond by introducing adjacent substituents has been demonstrated as a successful method for pr...

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Bibliographic Details
Main Authors: Saja Baraghithy, Reem Smoum, Malka Attar-Namdar, Raphael Mechoulam, Itai Bab, Joseph Tam
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:Molecules
Subjects:
bone lipids
<i>n</i>-acyl amide
oleoyl serine
osteoporosis
bone marrow adiposity
Online Access:https://www.mdpi.com/1420-3049/24/20/3719

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