Pulse Rate Measurement During Sleep Using Wearable Sensors, and its Correlation with the Menstrual Cycle Phases, A Prospective Observational Study

Abstract An affordable, user-friendly fertility-monitoring tool remains an unmet need. We examine in this study the correlation between pulse rate (PR) and the menstrual phases using wrist-worn PR sensors. 91 healthy, non-pregnant women, between 22–42 years old, were recruited for a prospective-obse...

Full description

Bibliographic Details
Main Authors: Mohaned Shilaih, Valérie de Clerck, Lisa Falco, Florian Kübler, Brigitte Leeners
Format: Article
Language:English
Published: Nature Publishing Group 2017-05-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-01433-9
id doaj-ea96f66669554243ba78250b61236cbe
record_format Article
spelling doaj-ea96f66669554243ba78250b61236cbe2020-12-08T00:57:44ZengNature Publishing GroupScientific Reports2045-23222017-05-01711710.1038/s41598-017-01433-9Pulse Rate Measurement During Sleep Using Wearable Sensors, and its Correlation with the Menstrual Cycle Phases, A Prospective Observational StudyMohaned Shilaih0Valérie de Clerck1Lisa Falco2Florian Kübler3Brigitte Leeners4Department of Reproductive Endocrinology, University Hospital ZurichAva AGAva AGAva AGDepartment of Reproductive Endocrinology, University Hospital ZurichAbstract An affordable, user-friendly fertility-monitoring tool remains an unmet need. We examine in this study the correlation between pulse rate (PR) and the menstrual phases using wrist-worn PR sensors. 91 healthy, non-pregnant women, between 22–42 years old, were recruited for a prospective-observational clinical trial. Participants measured PR during sleep using wrist-worn bracelets with photoplethysmographic sensors. Ovulation day was estimated with “Clearblue Digital-Ovulation-urine test”. Potential behavioral and nutritional confounders were collected daily. 274 ovulatory cycles were recorded from 91 eligible women, with a mean cycle length of 27.3 days (±2.7). We observed a significant increase in PR during the fertile window compared to the menstrual phase (2.1 beat-per-minute, p < 0.01). Moreover, PR during the mid-luteal phase was also significantly elevated compared to the fertile window (1.8 beat-per-minute, p < 0.01), and the menstrual phase (3.8 beat-per-minute, p < 0.01). PR increase in the ovulatory and mid-luteal phase was robust to adjustment for the collected confounders. There is a significant increase of the fertile-window PR (collected during sleep) compared to the menstrual phase. The aforementioned association was robust to the inter- and intra-person variability of menstrual-cycle length, behavioral, and nutritional profiles. Hence, PR monitoring using wearable sensors could be used as one parameter within a multi-parameter fertility awareness-based method.https://doi.org/10.1038/s41598-017-01433-9
collection DOAJ
language English
format Article
sources DOAJ
author Mohaned Shilaih
Valérie de Clerck
Lisa Falco
Florian Kübler
Brigitte Leeners
spellingShingle Mohaned Shilaih
Valérie de Clerck
Lisa Falco
Florian Kübler
Brigitte Leeners
Pulse Rate Measurement During Sleep Using Wearable Sensors, and its Correlation with the Menstrual Cycle Phases, A Prospective Observational Study
Scientific Reports
author_facet Mohaned Shilaih
Valérie de Clerck
Lisa Falco
Florian Kübler
Brigitte Leeners
author_sort Mohaned Shilaih
title Pulse Rate Measurement During Sleep Using Wearable Sensors, and its Correlation with the Menstrual Cycle Phases, A Prospective Observational Study
title_short Pulse Rate Measurement During Sleep Using Wearable Sensors, and its Correlation with the Menstrual Cycle Phases, A Prospective Observational Study
title_full Pulse Rate Measurement During Sleep Using Wearable Sensors, and its Correlation with the Menstrual Cycle Phases, A Prospective Observational Study
title_fullStr Pulse Rate Measurement During Sleep Using Wearable Sensors, and its Correlation with the Menstrual Cycle Phases, A Prospective Observational Study
title_full_unstemmed Pulse Rate Measurement During Sleep Using Wearable Sensors, and its Correlation with the Menstrual Cycle Phases, A Prospective Observational Study
title_sort pulse rate measurement during sleep using wearable sensors, and its correlation with the menstrual cycle phases, a prospective observational study
publisher Nature Publishing Group
series Scientific Reports
issn 2045-2322
publishDate 2017-05-01
description Abstract An affordable, user-friendly fertility-monitoring tool remains an unmet need. We examine in this study the correlation between pulse rate (PR) and the menstrual phases using wrist-worn PR sensors. 91 healthy, non-pregnant women, between 22–42 years old, were recruited for a prospective-observational clinical trial. Participants measured PR during sleep using wrist-worn bracelets with photoplethysmographic sensors. Ovulation day was estimated with “Clearblue Digital-Ovulation-urine test”. Potential behavioral and nutritional confounders were collected daily. 274 ovulatory cycles were recorded from 91 eligible women, with a mean cycle length of 27.3 days (±2.7). We observed a significant increase in PR during the fertile window compared to the menstrual phase (2.1 beat-per-minute, p < 0.01). Moreover, PR during the mid-luteal phase was also significantly elevated compared to the fertile window (1.8 beat-per-minute, p < 0.01), and the menstrual phase (3.8 beat-per-minute, p < 0.01). PR increase in the ovulatory and mid-luteal phase was robust to adjustment for the collected confounders. There is a significant increase of the fertile-window PR (collected during sleep) compared to the menstrual phase. The aforementioned association was robust to the inter- and intra-person variability of menstrual-cycle length, behavioral, and nutritional profiles. Hence, PR monitoring using wearable sensors could be used as one parameter within a multi-parameter fertility awareness-based method.
url https://doi.org/10.1038/s41598-017-01433-9
work_keys_str_mv AT mohanedshilaih pulseratemeasurementduringsleepusingwearablesensorsanditscorrelationwiththemenstrualcyclephasesaprospectiveobservationalstudy
AT valeriedeclerck pulseratemeasurementduringsleepusingwearablesensorsanditscorrelationwiththemenstrualcyclephasesaprospectiveobservationalstudy
AT lisafalco pulseratemeasurementduringsleepusingwearablesensorsanditscorrelationwiththemenstrualcyclephasesaprospectiveobservationalstudy
AT floriankubler pulseratemeasurementduringsleepusingwearablesensorsanditscorrelationwiththemenstrualcyclephasesaprospectiveobservationalstudy
AT brigitteleeners pulseratemeasurementduringsleepusingwearablesensorsanditscorrelationwiththemenstrualcyclephasesaprospectiveobservationalstudy
_version_ 1724395482867826688