Mice left out in the cold: commentary on the phenotype of TRPM8-nulls
<p>Abstract</p> <p>Detection of innocuous temperatures allows an organism to select an appropriate environmental climate, while the ability to recognize noxious temperature extremes warns of impending tissue damage. For temperatures considered cold, the menthol receptor TRPM8 is ac...
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2007-08-01
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Series: | Molecular Pain |
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doaj-ea97d39ce118451c8d127bc9d73e62bd2020-11-25T03:59:48ZengSAGE PublishingMolecular Pain1744-80692007-08-01312310.1186/1744-8069-3-23Mice left out in the cold: commentary on the phenotype of TRPM8-nullsMcKemy David DDaniels Richard L<p>Abstract</p> <p>Detection of innocuous temperatures allows an organism to select an appropriate environmental climate, while the ability to recognize noxious temperature extremes warns of impending tissue damage. For temperatures considered cold, the menthol receptor TRPM8 is activated when temperatures drop below ~26°C, thus making it an intriguing candidate as the molecular mediator of cold perception. However, confirmation of this hypothesis in vivo has eluded researchers until recently. Three independent research groups have reported that mice lacking this single gene are severely impaired in their ability to detect cold temperatures. Remarkably, these animals are deficient in many diverse aspects of cold signaling, including cool and noxious cold perception, injury-evoked sensitization to cold, and cooling-induced analgesia. These animals provide a great deal of insight into the molecular signaling pathways that participate in the detection of cold and painful stimuli.</p> http://www.molecularpain.com/content/3/1/23 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
McKemy David D Daniels Richard L |
spellingShingle |
McKemy David D Daniels Richard L Mice left out in the cold: commentary on the phenotype of TRPM8-nulls Molecular Pain |
author_facet |
McKemy David D Daniels Richard L |
author_sort |
McKemy David D |
title |
Mice left out in the cold: commentary on the phenotype of TRPM8-nulls |
title_short |
Mice left out in the cold: commentary on the phenotype of TRPM8-nulls |
title_full |
Mice left out in the cold: commentary on the phenotype of TRPM8-nulls |
title_fullStr |
Mice left out in the cold: commentary on the phenotype of TRPM8-nulls |
title_full_unstemmed |
Mice left out in the cold: commentary on the phenotype of TRPM8-nulls |
title_sort |
mice left out in the cold: commentary on the phenotype of trpm8-nulls |
publisher |
SAGE Publishing |
series |
Molecular Pain |
issn |
1744-8069 |
publishDate |
2007-08-01 |
description |
<p>Abstract</p> <p>Detection of innocuous temperatures allows an organism to select an appropriate environmental climate, while the ability to recognize noxious temperature extremes warns of impending tissue damage. For temperatures considered cold, the menthol receptor TRPM8 is activated when temperatures drop below ~26°C, thus making it an intriguing candidate as the molecular mediator of cold perception. However, confirmation of this hypothesis in vivo has eluded researchers until recently. Three independent research groups have reported that mice lacking this single gene are severely impaired in their ability to detect cold temperatures. Remarkably, these animals are deficient in many diverse aspects of cold signaling, including cool and noxious cold perception, injury-evoked sensitization to cold, and cooling-induced analgesia. These animals provide a great deal of insight into the molecular signaling pathways that participate in the detection of cold and painful stimuli.</p> |
url |
http://www.molecularpain.com/content/3/1/23 |
work_keys_str_mv |
AT mckemydavidd miceleftoutinthecoldcommentaryonthephenotypeoftrpm8nulls AT danielsrichardl miceleftoutinthecoldcommentaryonthephenotypeoftrpm8nulls |
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