Summary: | Necrolytic migratory erythema (NME) is a rare skin condition, which is the first presenting manifestation in almost
70% of the patients with glucagonoma. It is characterized by well-defined scaly erythematous patches with crusted
erosion in annular appearance. The predominant areas are genital area, intertrigenous sites and lower extremities.
This article has presented the case who had a 5-month history of progressive erythematous scaling patches with
crusted erosion on acral, trunk and intertriginous areas. He had been treated for several months at another hospital
without definite diagnosis. Our investigations revealed diabetes mellitus and a 6.5x5.7x6.0 cm mass at pancreatic
head without liver metastasis. Percutaneous biopsy revealed monomorphic round cells with pleomorphic nuclei
which immunohistochemical staining revealed strongly positive for neuroendocrine tumor. The diagnosis of
probable glucagonoma associated with NME was established. Zinc supplement was initiated resulting in marked
improvement of his rash. He went to Fuda Hospital in China to receive cryosurgery for his pancreatic tumor. Up
until now, there has been no recurrence of his rash and his general condition remains stable for 3 years. However,
CT scan at 3 years after cryosurgery showed slight increase in size of pancreatic mass and increased degree of
diffuse dilatation of main pancreatic duct and side-branch. Thus, long term follow-up is mandatory to conclude
the outcome of cryosurgery for pancreatic cancer.
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