Necrolytic Migratory Erythema with Cryosurgery Intervention
Necrolytic migratory erythema (NME) is a rare skin condition, which is the first presenting manifestation in almost 70% of the patients with glucagonoma. It is characterized by well-defined scaly erythematous patches with crusted erosion in annular appearance. The predominant areas are genital are...
Main Authors: | , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Mahidol University
2017-01-01
|
Series: | Siriraj Medical Journal |
Subjects: | |
Online Access: | http://www.smj.si.mahidol.ac.th/sirirajmedj/index.php/smj/article/view/153/177 |
id |
doaj-ea9a2cb13a0f426bbe8d4c1e533e32fe |
---|---|
record_format |
Article |
spelling |
doaj-ea9a2cb13a0f426bbe8d4c1e533e32fe2020-11-24T23:08:54ZengMahidol UniversitySiriraj Medical Journal2228-80822017-01-01691444610.14456/smj.2017.9Necrolytic Migratory Erythema with Cryosurgery InterventionKamolwan Pongparit0Leena Chularojanamontri1Waranya Boonchai2Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol UniversityDepartment of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol UniversityDepartment of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol UniversityNecrolytic migratory erythema (NME) is a rare skin condition, which is the first presenting manifestation in almost 70% of the patients with glucagonoma. It is characterized by well-defined scaly erythematous patches with crusted erosion in annular appearance. The predominant areas are genital area, intertrigenous sites and lower extremities. This article has presented the case who had a 5-month history of progressive erythematous scaling patches with crusted erosion on acral, trunk and intertriginous areas. He had been treated for several months at another hospital without definite diagnosis. Our investigations revealed diabetes mellitus and a 6.5x5.7x6.0 cm mass at pancreatic head without liver metastasis. Percutaneous biopsy revealed monomorphic round cells with pleomorphic nuclei which immunohistochemical staining revealed strongly positive for neuroendocrine tumor. The diagnosis of probable glucagonoma associated with NME was established. Zinc supplement was initiated resulting in marked improvement of his rash. He went to Fuda Hospital in China to receive cryosurgery for his pancreatic tumor. Up until now, there has been no recurrence of his rash and his general condition remains stable for 3 years. However, CT scan at 3 years after cryosurgery showed slight increase in size of pancreatic mass and increased degree of diffuse dilatation of main pancreatic duct and side-branch. Thus, long term follow-up is mandatory to conclude the outcome of cryosurgery for pancreatic cancer.http://www.smj.si.mahidol.ac.th/sirirajmedj/index.php/smj/article/view/153/177Cryosurgery; glucagonoma; necrolytic migratory erythema (Siriraj Med J 2017;69:44-46) |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Kamolwan Pongparit Leena Chularojanamontri Waranya Boonchai |
spellingShingle |
Kamolwan Pongparit Leena Chularojanamontri Waranya Boonchai Necrolytic Migratory Erythema with Cryosurgery Intervention Siriraj Medical Journal Cryosurgery; glucagonoma; necrolytic migratory erythema (Siriraj Med J 2017;69:44-46) |
author_facet |
Kamolwan Pongparit Leena Chularojanamontri Waranya Boonchai |
author_sort |
Kamolwan Pongparit |
title |
Necrolytic Migratory Erythema with Cryosurgery Intervention |
title_short |
Necrolytic Migratory Erythema with Cryosurgery Intervention |
title_full |
Necrolytic Migratory Erythema with Cryosurgery Intervention |
title_fullStr |
Necrolytic Migratory Erythema with Cryosurgery Intervention |
title_full_unstemmed |
Necrolytic Migratory Erythema with Cryosurgery Intervention |
title_sort |
necrolytic migratory erythema with cryosurgery intervention |
publisher |
Mahidol University |
series |
Siriraj Medical Journal |
issn |
2228-8082 |
publishDate |
2017-01-01 |
description |
Necrolytic migratory erythema (NME) is a rare skin condition, which is the first presenting manifestation in almost
70% of the patients with glucagonoma. It is characterized by well-defined scaly erythematous patches with crusted
erosion in annular appearance. The predominant areas are genital area, intertrigenous sites and lower extremities.
This article has presented the case who had a 5-month history of progressive erythematous scaling patches with
crusted erosion on acral, trunk and intertriginous areas. He had been treated for several months at another hospital
without definite diagnosis. Our investigations revealed diabetes mellitus and a 6.5x5.7x6.0 cm mass at pancreatic
head without liver metastasis. Percutaneous biopsy revealed monomorphic round cells with pleomorphic nuclei
which immunohistochemical staining revealed strongly positive for neuroendocrine tumor. The diagnosis of
probable glucagonoma associated with NME was established. Zinc supplement was initiated resulting in marked
improvement of his rash. He went to Fuda Hospital in China to receive cryosurgery for his pancreatic tumor. Up
until now, there has been no recurrence of his rash and his general condition remains stable for 3 years. However,
CT scan at 3 years after cryosurgery showed slight increase in size of pancreatic mass and increased degree of
diffuse dilatation of main pancreatic duct and side-branch. Thus, long term follow-up is mandatory to conclude
the outcome of cryosurgery for pancreatic cancer. |
topic |
Cryosurgery; glucagonoma; necrolytic migratory erythema (Siriraj Med J 2017;69:44-46) |
url |
http://www.smj.si.mahidol.ac.th/sirirajmedj/index.php/smj/article/view/153/177 |
work_keys_str_mv |
AT kamolwanpongparit necrolyticmigratoryerythemawithcryosurgeryintervention AT leenachularojanamontri necrolyticmigratoryerythemawithcryosurgeryintervention AT waranyaboonchai necrolyticmigratoryerythemawithcryosurgeryintervention |
_version_ |
1725612504840667136 |