Antibacterial and anti-inflammatory effects of lime (citrus aurantifolia) peel extract in mice balb/c induced salmonella typhi
Lime (Citrus aurantifolia) is a traditional plant that is widely used as antibacterial. This study to prove the effect of lime peel extract (LPE) on the growth of bacterial colonization of S. Typhi medited by activity of IL-6. True experimental pre-post test design, mice were divided into; LPE 510...
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doaj-ea9ceed2ba694456a6650eb38897cec52020-11-25T03:27:42ZengPAGEPress PublicationsJournal of Biological Research1826-88382284-02302020-09-0110.4081/jbr.0.8951Antibacterial and anti-inflammatory effects of lime (citrus aurantifolia) peel extract in mice balb/c induced salmonella typhiVivien Novarina Kasim0Mochammad Hatta1Rosdiana Natzir2Veni Hadju3Yusminah Hala4Budu Budu5Gemini Alam6Suryani As'ad7Ami Febriza8Hasta Handayani Idrus9Faculty of Medicine, Gorontalo State UniversityMolecular Biology and Immunology Laboratory,Department of Microbiology,Faculty of Medicine,Hasanuddin University,Makassar,IndonesiaDepartment of Biochemistry, Faculty of Medicine, Hasanuddin University, Makassar, IndonesiaDepartment of Nutrition, Faculty of Public Health, Hasanuddin University, Makassar, IndonesiaDepartement of Biology, Faculty of Mathematics and Natural Science, Makassar State University, Makassar, IndonesiaDepartment of Ophthalmology, Faculty of Medicine, Hasanuddin University, Makassar, IndonesiaDepartment of Pharmacognosy, Faculty of Pharmacy, Hasanuddin University, Makassar, IndonesiaDepartment of Clinical Nutrition, Faculty of Medicine, Hasanuddin University, Makassar, IndonesiaDepartment of Physiology, Faculty of Medicine, Muhammadiyah University Makassar, Makassar, IndonesiaDepartment of Microbiology, Indonesian Muslim University, Makassar, Indonesia Lime (Citrus aurantifolia) is a traditional plant that is widely used as antibacterial. This study to prove the effect of lime peel extract (LPE) on the growth of bacterial colonization of S. Typhi medited by activity of IL-6. True experimental pre-post test design, mice were divided into; LPE 510 mg/kgbw, LPE 750 mg/kgbw, positive and negative control. The examination was carried out 3 times, the 5th day before the intervention, the 10th day after the intervention and the 30th day after maintenance. Intervention LPE for 5 days can decreased the number of S. Typhi colonies, even maintenance for 20 days after the intervention showed no bacterial growth . IL-6 pro-inflammatory cytokine activity increased on examination day 5 after S.Typhi injection and decreased after intervention on day 10, significantly different between pre and post at all groups except negative controls (p=0.15). The speed of decrease in IL-6 levels was greatest at the LPE 750 mg/kgbw (velocity=-5.64%). LPE decreased serum levels of IL-6 and inhibit the growth of S. Typhi colony in mice Balb/c. LPE have potential as antibacterial and anti-inflammatory. https://www.pagepressjournals.org/index.php/jbr/article/view/8951Lime peel extractCitrus aurantifoliaInterleukin 6antibacterialanti-inflammatory |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Vivien Novarina Kasim Mochammad Hatta Rosdiana Natzir Veni Hadju Yusminah Hala Budu Budu Gemini Alam Suryani As'ad Ami Febriza Hasta Handayani Idrus |
spellingShingle |
Vivien Novarina Kasim Mochammad Hatta Rosdiana Natzir Veni Hadju Yusminah Hala Budu Budu Gemini Alam Suryani As'ad Ami Febriza Hasta Handayani Idrus Antibacterial and anti-inflammatory effects of lime (citrus aurantifolia) peel extract in mice balb/c induced salmonella typhi Journal of Biological Research Lime peel extract Citrus aurantifolia Interleukin 6 antibacterial anti-inflammatory |
author_facet |
Vivien Novarina Kasim Mochammad Hatta Rosdiana Natzir Veni Hadju Yusminah Hala Budu Budu Gemini Alam Suryani As'ad Ami Febriza Hasta Handayani Idrus |
author_sort |
Vivien Novarina Kasim |
title |
Antibacterial and anti-inflammatory effects of lime (citrus aurantifolia) peel extract in mice balb/c induced salmonella typhi |
title_short |
Antibacterial and anti-inflammatory effects of lime (citrus aurantifolia) peel extract in mice balb/c induced salmonella typhi |
title_full |
Antibacterial and anti-inflammatory effects of lime (citrus aurantifolia) peel extract in mice balb/c induced salmonella typhi |
title_fullStr |
Antibacterial and anti-inflammatory effects of lime (citrus aurantifolia) peel extract in mice balb/c induced salmonella typhi |
title_full_unstemmed |
Antibacterial and anti-inflammatory effects of lime (citrus aurantifolia) peel extract in mice balb/c induced salmonella typhi |
title_sort |
antibacterial and anti-inflammatory effects of lime (citrus aurantifolia) peel extract in mice balb/c induced salmonella typhi |
publisher |
PAGEPress Publications |
series |
Journal of Biological Research |
issn |
1826-8838 2284-0230 |
publishDate |
2020-09-01 |
description |
Lime (Citrus aurantifolia) is a traditional plant that is widely used as antibacterial. This study to prove the effect of lime peel extract (LPE) on the growth of bacterial colonization of S. Typhi medited by activity of IL-6. True experimental pre-post test design, mice were divided into; LPE 510 mg/kgbw, LPE 750 mg/kgbw, positive and negative control. The examination was carried out 3 times, the 5th day before the intervention, the 10th day after the intervention and the 30th day after maintenance. Intervention LPE for 5 days can decreased the number of S. Typhi colonies, even maintenance for 20 days after the intervention showed no bacterial growth . IL-6 pro-inflammatory cytokine activity increased on examination day 5 after S.Typhi injection and decreased after intervention on day 10, significantly different between pre and post at all groups except negative controls (p=0.15). The speed of decrease in IL-6 levels was greatest at the LPE 750 mg/kgbw (velocity=-5.64%). LPE decreased serum levels of IL-6 and inhibit the growth of S. Typhi colony in mice Balb/c. LPE have potential as antibacterial and anti-inflammatory.
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topic |
Lime peel extract Citrus aurantifolia Interleukin 6 antibacterial anti-inflammatory |
url |
https://www.pagepressjournals.org/index.php/jbr/article/view/8951 |
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