Loss of MeCP2 disrupts cell autonomous and autocrine BDNF signaling in mouse glutamatergic neurons

Loss of MeCP2 disrupts cell autonomous and autocrine BDNF signaling in mouse glutamatergic neurons

Mutations in the MECP2 gene cause the neurodevelopmental disorder Rett syndrome (RTT). Previous studies have shown that altered MeCP2 levels result in aberrant neurite outgrowth and glutamatergic synapse formation. However, causal molecular mechanisms are not well understood since MeCP2 is known to...

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Bibliographic Details
Main Authors: Charanya Sampathkumar, Yuan-Ju Wu, Mayur Vadhvani, Thorsten Trimbuch, Britta Eickholt, Christian Rosenmund
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-10-01
Series:eLife
Subjects:
Rett syndrome
synaptic transmission
glutamatergic
BDNF
cell autonomous
Online Access:https://elifesciences.org/articles/19374

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