Higher Omega-3 Index Is Associated with Better Asthma Control and Lower Medication Dose: A Cross-Sectional Study
Asthma is a chronic inflammatory airway disease, associated with systemic inflammation. Omega-3 polyunsaturated fatty acids (n-3 PUFA) have established anti-inflammatory effects, thus having potential as an adjunct therapy in asthma. This study aimed to compare erythrocyte n-3 PUFA in adults with (&...
Main Authors: | , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2019-12-01
|
Series: | Nutrients |
Subjects: | |
Online Access: | https://www.mdpi.com/2072-6643/12/1/74 |
id |
doaj-eaa0f762927348bcb260fcf89ee4d296 |
---|---|
record_format |
Article |
spelling |
doaj-eaa0f762927348bcb260fcf89ee4d2962020-11-25T02:23:31ZengMDPI AGNutrients2072-66432019-12-011217410.3390/nu12010074nu12010074Higher Omega-3 Index Is Associated with Better Asthma Control and Lower Medication Dose: A Cross-Sectional StudyIsobel Stoodley0Manohar Garg1Hayley Scott2Lesley Macdonald-Wicks3Bronwyn Berthon4Lisa Wood5Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute, Newcastle, NSW 2305, AustraliaSchool of Biomedical Science and Pharmacy, University of Newcastle, Callaghan, NSW 2308, AustraliaPriority Research Centre for Healthy Lungs, Hunter Medical Research Institute, Newcastle, NSW 2305, AustraliaSchool of Health Sciences, University of Newcastle, Callaghan, NSW 2308, AustraliaPriority Research Centre for Healthy Lungs, Hunter Medical Research Institute, Newcastle, NSW 2305, AustraliaPriority Research Centre for Healthy Lungs, Hunter Medical Research Institute, Newcastle, NSW 2305, AustraliaAsthma is a chronic inflammatory airway disease, associated with systemic inflammation. Omega-3 polyunsaturated fatty acids (n-3 PUFA) have established anti-inflammatory effects, thus having potential as an adjunct therapy in asthma. This study aimed to compare erythrocyte n-3 PUFA in adults with (<i>n</i> = 255) and without (<i>n</i> = 137) asthma and determine the relationship between erythrocyte n-3 PUFA and clinical asthma outcomes. Subjects had blood collected, lung function measured and Juniper Asthma Control Questionnaire (ACQ) score calculated. Fatty acids were measured in erythrocyte membranes by gas chromatography, and the omega-3 index (O3I) was calculated (% eicosapentaenoic acid + % docosahexaenoic acid). O3I was similar in subjects with and without asthma (<i>p</i> = 0.089). A higher O3I was observed in subjects with controlled or partially controlled asthma (ACQ < 1.5) compared to subjects with uncontrolled asthma (ACQ ≥ 1.5) (6.0% (5.4−7.2) versus 5.6% (4.6−6.4) <i>p</i> = 0.033). Subjects with a high O3I (≥8%) had a lower maintenance dose of inhaled corticosteroids (ICS) compared to those with a low O3I (<8%) (1000 μg (400−1000) versus 1000 μg (500−2000) <i>p</i> = 0.019). This study demonstrates that a higher O3I is associated with better asthma control and with lower ICS dose, suggesting that a higher erythrocyte n-3 PUFA level may have a role in asthma management.https://www.mdpi.com/2072-6643/12/1/74omega-3 indexasthmainflammationfatty acidsnutritional biomarkers |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Isobel Stoodley Manohar Garg Hayley Scott Lesley Macdonald-Wicks Bronwyn Berthon Lisa Wood |
spellingShingle |
Isobel Stoodley Manohar Garg Hayley Scott Lesley Macdonald-Wicks Bronwyn Berthon Lisa Wood Higher Omega-3 Index Is Associated with Better Asthma Control and Lower Medication Dose: A Cross-Sectional Study Nutrients omega-3 index asthma inflammation fatty acids nutritional biomarkers |
author_facet |
Isobel Stoodley Manohar Garg Hayley Scott Lesley Macdonald-Wicks Bronwyn Berthon Lisa Wood |
author_sort |
Isobel Stoodley |
title |
Higher Omega-3 Index Is Associated with Better Asthma Control and Lower Medication Dose: A Cross-Sectional Study |
title_short |
Higher Omega-3 Index Is Associated with Better Asthma Control and Lower Medication Dose: A Cross-Sectional Study |
title_full |
Higher Omega-3 Index Is Associated with Better Asthma Control and Lower Medication Dose: A Cross-Sectional Study |
title_fullStr |
Higher Omega-3 Index Is Associated with Better Asthma Control and Lower Medication Dose: A Cross-Sectional Study |
title_full_unstemmed |
Higher Omega-3 Index Is Associated with Better Asthma Control and Lower Medication Dose: A Cross-Sectional Study |
title_sort |
higher omega-3 index is associated with better asthma control and lower medication dose: a cross-sectional study |
publisher |
MDPI AG |
series |
Nutrients |
issn |
2072-6643 |
publishDate |
2019-12-01 |
description |
Asthma is a chronic inflammatory airway disease, associated with systemic inflammation. Omega-3 polyunsaturated fatty acids (n-3 PUFA) have established anti-inflammatory effects, thus having potential as an adjunct therapy in asthma. This study aimed to compare erythrocyte n-3 PUFA in adults with (<i>n</i> = 255) and without (<i>n</i> = 137) asthma and determine the relationship between erythrocyte n-3 PUFA and clinical asthma outcomes. Subjects had blood collected, lung function measured and Juniper Asthma Control Questionnaire (ACQ) score calculated. Fatty acids were measured in erythrocyte membranes by gas chromatography, and the omega-3 index (O3I) was calculated (% eicosapentaenoic acid + % docosahexaenoic acid). O3I was similar in subjects with and without asthma (<i>p</i> = 0.089). A higher O3I was observed in subjects with controlled or partially controlled asthma (ACQ < 1.5) compared to subjects with uncontrolled asthma (ACQ ≥ 1.5) (6.0% (5.4−7.2) versus 5.6% (4.6−6.4) <i>p</i> = 0.033). Subjects with a high O3I (≥8%) had a lower maintenance dose of inhaled corticosteroids (ICS) compared to those with a low O3I (<8%) (1000 μg (400−1000) versus 1000 μg (500−2000) <i>p</i> = 0.019). This study demonstrates that a higher O3I is associated with better asthma control and with lower ICS dose, suggesting that a higher erythrocyte n-3 PUFA level may have a role in asthma management. |
topic |
omega-3 index asthma inflammation fatty acids nutritional biomarkers |
url |
https://www.mdpi.com/2072-6643/12/1/74 |
work_keys_str_mv |
AT isobelstoodley higheromega3indexisassociatedwithbetterasthmacontrolandlowermedicationdoseacrosssectionalstudy AT manohargarg higheromega3indexisassociatedwithbetterasthmacontrolandlowermedicationdoseacrosssectionalstudy AT hayleyscott higheromega3indexisassociatedwithbetterasthmacontrolandlowermedicationdoseacrosssectionalstudy AT lesleymacdonaldwicks higheromega3indexisassociatedwithbetterasthmacontrolandlowermedicationdoseacrosssectionalstudy AT bronwynberthon higheromega3indexisassociatedwithbetterasthmacontrolandlowermedicationdoseacrosssectionalstudy AT lisawood higheromega3indexisassociatedwithbetterasthmacontrolandlowermedicationdoseacrosssectionalstudy |
_version_ |
1724859131444068352 |