Physiologically-Based Pharmacokinetic (PBPK) Modeling of Buprenorphine in Adults, Children and Preterm Neonates

Physiologically-Based Pharmacokinetic (PBPK) Modeling of Buprenorphine in Adults, Children and Preterm Neonates

Buprenorphine plays a crucial role in the therapeutic management of pain in adults, adolescents and pediatric subpopulations. However, only few pharmacokinetic studies of buprenorphine in children, particularly neonates, are available as conducting clinical trials in this population is especially ch...

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Bibliographic Details
Main Authors:	Lukas Kovar, Christina Schräpel, Dominik Selzer, Yvonne Kohl, Robert Bals, Matthias Schwab, Thorsten Lehr
Format:	Article
Language:	English
Published:	MDPI AG 2020-06-01
Series:	Pharmaceutics
Subjects:	physiologically based pharmacokinetic (PBPK) modeling buprenorphine drug-drug interaction (DDI) norbuprenorphine pediatric scaling pharmacokinetics
Online Access:	https://www.mdpi.com/1999-4923/12/6/578

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