Phase II Trial of Dolastatin-10, a Novel Anti-Tubulin Agent, in Metastatic Soft Tissue Sarcomas
Patients:Soft tissue sarcomas are uncommon malignancies with few therapeutic options for recurrent or metastatic disease. Dolastatin-10 (Dol-10) is a pentapeptide anti-microtubule agent that binds to tubulin sites distinct from vinca alkaloids. Based on the novel mechanism of action, limited activit...
Main Authors: | M. von Mehren, S. P. Balcerzak, A. S. Kraft, J. H. Edmonson, S. H. Okuno, M. Davey, S. Mclaughlin, M. T. Beard, A. Rogatko |
---|---|
Format: | Article |
Language: | English |
Published: |
Hindawi Limited
2004-01-01
|
Series: | Sarcoma |
Online Access: | http://dx.doi.org/10.1155/2004/924913 |
Similar Items
-
Synthesis and Biological Activity of Dolastatin 15 Analogs
by: 黃維生
Published: (1997) -
New drugs and combinations for the treatment of soft-tissue sarcoma: a review
by: von Mehren M, et al.
Published: (2012-11-01) -
Treatment Strategies for Metastatic Soft Tissue Sarcomas
by: Lisette M. Wiltink, et al.
Published: (2021-04-01) -
Synthesis and Evaluation of Linear and Macrocyclic Dolastatin 10 Analogues Containing Pyrrolidine Ring Modifications
by: Michinori Akaiwa, et al.
Published: (2018-05-01) -
Marine Antitumor Peptide Dolastatin 10: Biological Activity, Structural Modification and Synthetic Chemistry
by: Gang Gao, et al.
Published: (2021-06-01)