Alectinib-Induced Pleural and Pericardial Effusions in ALK-Positive NSCLC
Alectinib is the first-line targeted treatment for advanced ALK-positive non-small-cell lung cancer. Although it has a relatively mild toxicity profile, adverse events (AEs) do occur. We present a case of alectinib-induced bilateral pleural effusions and pericardial effusion that has not previously...
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doaj-eaabbf6bfe18449eb5367df6e94ada0f2021-10-07T13:44:28ZengKarger PublishersCase Reports in Oncology1662-65752021-09-011431323132710.1159/000518081518081Alectinib-Induced Pleural and Pericardial Effusions in ALK-Positive NSCLCMaiken Parm Ulhoi0https://orcid.org/0000-0001-6482-8139Boe Sandahl Sorensen1Peter Meldgaard2Department of Oncology, Aarhus University Hospital, Aarhus, DenmarkDepartment of Clinical Biochemistry, Aarhus University Hospital, Aarhus, DenmarkDepartment of Oncology, Aarhus University Hospital, Aarhus, DenmarkAlectinib is the first-line targeted treatment for advanced ALK-positive non-small-cell lung cancer. Although it has a relatively mild toxicity profile, adverse events (AEs) do occur. We present a case of alectinib-induced bilateral pleural effusions and pericardial effusion that has not previously been reported. The patient developed severe dyspnea 3 months after starting alectinib. He underwent thorough clinical examination including evaluations of heart function. The heart function was normal. There was no sign of pneumonitis or progressive disease on the CT scans. Cytology samples of the pleural fluid from multiple thoracocenteses were examined and showed no malignant cells. Next-generation sequencing (NGS) analysis of circulating tumor DNA from sequential blood samples was also carried out. NGS identified no known driver mutations associated with the effusions. Hence, the effusions were suspected to be an alectinib-induced AE. Alectinib was withdrawn, and the patient commenced brigatinib. The effusions subsequently regressed.https://www.karger.com/Article/FullText/518081alectinibpleural effusionpericardial effusionnon-small-cell lung cancer |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Maiken Parm Ulhoi Boe Sandahl Sorensen Peter Meldgaard |
spellingShingle |
Maiken Parm Ulhoi Boe Sandahl Sorensen Peter Meldgaard Alectinib-Induced Pleural and Pericardial Effusions in ALK-Positive NSCLC Case Reports in Oncology alectinib pleural effusion pericardial effusion non-small-cell lung cancer |
author_facet |
Maiken Parm Ulhoi Boe Sandahl Sorensen Peter Meldgaard |
author_sort |
Maiken Parm Ulhoi |
title |
Alectinib-Induced Pleural and Pericardial Effusions in ALK-Positive NSCLC |
title_short |
Alectinib-Induced Pleural and Pericardial Effusions in ALK-Positive NSCLC |
title_full |
Alectinib-Induced Pleural and Pericardial Effusions in ALK-Positive NSCLC |
title_fullStr |
Alectinib-Induced Pleural and Pericardial Effusions in ALK-Positive NSCLC |
title_full_unstemmed |
Alectinib-Induced Pleural and Pericardial Effusions in ALK-Positive NSCLC |
title_sort |
alectinib-induced pleural and pericardial effusions in alk-positive nsclc |
publisher |
Karger Publishers |
series |
Case Reports in Oncology |
issn |
1662-6575 |
publishDate |
2021-09-01 |
description |
Alectinib is the first-line targeted treatment for advanced ALK-positive non-small-cell lung cancer. Although it has a relatively mild toxicity profile, adverse events (AEs) do occur. We present a case of alectinib-induced bilateral pleural effusions and pericardial effusion that has not previously been reported. The patient developed severe dyspnea 3 months after starting alectinib. He underwent thorough clinical examination including evaluations of heart function. The heart function was normal. There was no sign of pneumonitis or progressive disease on the CT scans. Cytology samples of the pleural fluid from multiple thoracocenteses were examined and showed no malignant cells. Next-generation sequencing (NGS) analysis of circulating tumor DNA from sequential blood samples was also carried out. NGS identified no known driver mutations associated with the effusions. Hence, the effusions were suspected to be an alectinib-induced AE. Alectinib was withdrawn, and the patient commenced brigatinib. The effusions subsequently regressed. |
topic |
alectinib pleural effusion pericardial effusion non-small-cell lung cancer |
url |
https://www.karger.com/Article/FullText/518081 |
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