No hints at glyphosate-induced ruminal dysbiosis in cows
Abstract Glyphosate-based herbicides are among the most used non-selective herbicides worldwide and inhibit synthesis of aromatic amino acids in plants, bacteria, and fungi. Given the broad usage, controversies concerning potential effects of glyphosate on health and especially on gut microbiomes ar...
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Online Access: | https://doi.org/10.1038/s41522-021-00198-4 |
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doaj-eab7ea2ecfbe41dca4e5bb5e133b5e202021-03-28T11:43:48ZengNature Publishing Groupnpj Biofilms and Microbiomes2055-50082021-03-017111310.1038/s41522-021-00198-4No hints at glyphosate-induced ruminal dysbiosis in cowsFabian Billenkamp0Karina Schnabel1Liane Hüther2Jana Frahm3Dirk von Soosten4Ulrich Meyer5Dirk Höper6Martin Beer7Christian Seyboldt8Heinrich Neubauer9Sven Dänicke10Institute of Animal Nutrition, Federal Research Institute for Animal Health, Friedrich-Loeffler-InstituteInstitute of Animal Nutrition, Federal Research Institute for Animal Health, Friedrich-Loeffler-InstituteInstitute of Animal Nutrition, Federal Research Institute for Animal Health, Friedrich-Loeffler-InstituteInstitute of Animal Nutrition, Federal Research Institute for Animal Health, Friedrich-Loeffler-InstituteInstitute of Animal Nutrition, Federal Research Institute for Animal Health, Friedrich-Loeffler-InstituteInstitute of Animal Nutrition, Federal Research Institute for Animal Health, Friedrich-Loeffler-InstituteInstitute of Diagnostic Virology, Federal Research Institute for Animal Health, Friedrich-Loeffler-InstituteInstitute of Diagnostic Virology, Federal Research Institute for Animal Health, Friedrich-Loeffler-InstituteInstitute of Bacterial Infections and Zoonoses, Federal Research Institute for Animal Health, Friedrich-Loeffler-InstituteInstitute of Bacterial Infections and Zoonoses, Federal Research Institute for Animal Health, Friedrich-Loeffler-InstituteInstitute of Animal Nutrition, Federal Research Institute for Animal Health, Friedrich-Loeffler-InstituteAbstract Glyphosate-based herbicides are among the most used non-selective herbicides worldwide and inhibit synthesis of aromatic amino acids in plants, bacteria, and fungi. Given the broad usage, controversies concerning potential effects of glyphosate on health and especially on gut microbiomes arose. For cattle, it has been proposed based on in vitro data that glyphosate has detrimental effects on the ruminal microbiome, which manifest as a specific inhibition of bacteria involved in fiber degradation and as an enrichment of specific pathogens. In the present study, glyphosate effects on the ruminal microbiome were analyzed in vivo using glyphosate contaminated feedstuffs with strong differences in dietary fiber and dietary energy content in order to reproduce the proposed detrimental glyphosate effects on the rumen microbiome. While significant impact of dietary factors on the ruminal microbiome and its products are pointed out, no adverse glyphosate effects on ruminal microbiome composition, diversity, and microbial metabolites are observed.https://doi.org/10.1038/s41522-021-00198-4 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Fabian Billenkamp Karina Schnabel Liane Hüther Jana Frahm Dirk von Soosten Ulrich Meyer Dirk Höper Martin Beer Christian Seyboldt Heinrich Neubauer Sven Dänicke |
spellingShingle |
Fabian Billenkamp Karina Schnabel Liane Hüther Jana Frahm Dirk von Soosten Ulrich Meyer Dirk Höper Martin Beer Christian Seyboldt Heinrich Neubauer Sven Dänicke No hints at glyphosate-induced ruminal dysbiosis in cows npj Biofilms and Microbiomes |
author_facet |
Fabian Billenkamp Karina Schnabel Liane Hüther Jana Frahm Dirk von Soosten Ulrich Meyer Dirk Höper Martin Beer Christian Seyboldt Heinrich Neubauer Sven Dänicke |
author_sort |
Fabian Billenkamp |
title |
No hints at glyphosate-induced ruminal dysbiosis in cows |
title_short |
No hints at glyphosate-induced ruminal dysbiosis in cows |
title_full |
No hints at glyphosate-induced ruminal dysbiosis in cows |
title_fullStr |
No hints at glyphosate-induced ruminal dysbiosis in cows |
title_full_unstemmed |
No hints at glyphosate-induced ruminal dysbiosis in cows |
title_sort |
no hints at glyphosate-induced ruminal dysbiosis in cows |
publisher |
Nature Publishing Group |
series |
npj Biofilms and Microbiomes |
issn |
2055-5008 |
publishDate |
2021-03-01 |
description |
Abstract Glyphosate-based herbicides are among the most used non-selective herbicides worldwide and inhibit synthesis of aromatic amino acids in plants, bacteria, and fungi. Given the broad usage, controversies concerning potential effects of glyphosate on health and especially on gut microbiomes arose. For cattle, it has been proposed based on in vitro data that glyphosate has detrimental effects on the ruminal microbiome, which manifest as a specific inhibition of bacteria involved in fiber degradation and as an enrichment of specific pathogens. In the present study, glyphosate effects on the ruminal microbiome were analyzed in vivo using glyphosate contaminated feedstuffs with strong differences in dietary fiber and dietary energy content in order to reproduce the proposed detrimental glyphosate effects on the rumen microbiome. While significant impact of dietary factors on the ruminal microbiome and its products are pointed out, no adverse glyphosate effects on ruminal microbiome composition, diversity, and microbial metabolites are observed. |
url |
https://doi.org/10.1038/s41522-021-00198-4 |
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