PK-sensitive PrP is infectious and shares basic structural features with PK-resistant PrP.

PK-sensitive PrP is infectious and shares basic structural features with PK-resistant PrP.

One of the main characteristics of the transmissible isoform of the prion protein (PrP(Sc)) is its partial resistance to proteinase K (PK) digestion. Diagnosis of prion disease typically relies upon immunodetection of PK-digested PrP(Sc) following Western blot or ELISA. More recently, researchers de...

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Bibliographic Details
Main Authors: Gustavo Sajnani, Christopher J Silva, Adriana Ramos, Miguel A Pastrana, Bruce C Onisko, Melissa L Erickson, Elizabeth M Antaki, Irina Dynin, Ester Vázquez-Fernández, Christina J Sigurdson, J Mark Carter, Jesús R Requena
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC3291653?pdf=render

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