TP53 Status and Response to Treatment in Breast Cancers

TP53 Status and Response to Treatment in Breast Cancers

The p53 wild-type protein plays an important role in cells as is shown by its fine regulation at different levels. Since its discovery, numerous mutations have been described. In breast cancers, p53 is mutated in almost 30% of cases, with a higher frequency in some tumor subtypes. TP53 mutation is r...

Full description

Bibliographic Details
Main Authors: Mariana Varna, Guilhem Bousquet, Louis-François Plassa, Philippe Bertheau, Anne Janin
Format: Article
Language:English
Published: Hindawi Limited 2011-01-01
Series:Journal of Biomedicine and Biotechnology
Online Access:http://dx.doi.org/10.1155/2011/284584
id doaj-eac4cc51467547bca8bdb269134720ab
record_format Article
spelling doaj-eac4cc51467547bca8bdb269134720ab2020-11-25T00:49:55ZengHindawi LimitedJournal of Biomedicine and Biotechnology1110-72431110-72512011-01-01201110.1155/2011/284584284584TP53 Status and Response to Treatment in Breast CancersMariana Varna0Guilhem Bousquet1Louis-François Plassa2Philippe Bertheau3Anne Janin4Université Paris Diderot, Sorbonne Paris Cité, Laboratoire de Pathologie, UMR-S 728, 75010 Paris, FranceUniversité Paris Diderot, Sorbonne Paris Cité, Laboratoire de Pathologie, UMR-S 728, 75010 Paris, FranceAP-HP-Hôpital Saint-Louis, Laboratoire de Biochimie, 75010 Paris, FranceUniversité Paris Diderot, Sorbonne Paris Cité, Laboratoire de Pathologie, UMR-S 728, 75010 Paris, FranceUniversité Paris Diderot, Sorbonne Paris Cité, Laboratoire de Pathologie, UMR-S 728, 75010 Paris, FranceThe p53 wild-type protein plays an important role in cells as is shown by its fine regulation at different levels. Since its discovery, numerous mutations have been described. In breast cancers, p53 is mutated in almost 30% of cases, with a higher frequency in some tumor subtypes. TP53 mutation is reported to be a factor for good prognosis in some studies, while in others it is a factor for poor prognosis. The explanation for these different results could be linked to the fact that the studies were performed on different tumor types and with different therapy regimens.http://dx.doi.org/10.1155/2011/284584
collection DOAJ
language English
format Article
sources DOAJ
author Mariana Varna
Guilhem Bousquet
Louis-François Plassa
Philippe Bertheau
Anne Janin
spellingShingle Mariana Varna
Guilhem Bousquet
Louis-François Plassa
Philippe Bertheau
Anne Janin
TP53 Status and Response to Treatment in Breast Cancers
Journal of Biomedicine and Biotechnology
author_facet Mariana Varna
Guilhem Bousquet
Louis-François Plassa
Philippe Bertheau
Anne Janin
author_sort Mariana Varna
title TP53 Status and Response to Treatment in Breast Cancers
title_short TP53 Status and Response to Treatment in Breast Cancers
title_full TP53 Status and Response to Treatment in Breast Cancers
title_fullStr TP53 Status and Response to Treatment in Breast Cancers
title_full_unstemmed TP53 Status and Response to Treatment in Breast Cancers
title_sort tp53 status and response to treatment in breast cancers
publisher Hindawi Limited
series Journal of Biomedicine and Biotechnology
issn 1110-7243
1110-7251
publishDate 2011-01-01
description The p53 wild-type protein plays an important role in cells as is shown by its fine regulation at different levels. Since its discovery, numerous mutations have been described. In breast cancers, p53 is mutated in almost 30% of cases, with a higher frequency in some tumor subtypes. TP53 mutation is reported to be a factor for good prognosis in some studies, while in others it is a factor for poor prognosis. The explanation for these different results could be linked to the fact that the studies were performed on different tumor types and with different therapy regimens.
url http://dx.doi.org/10.1155/2011/284584
work_keys_str_mv AT marianavarna tp53statusandresponsetotreatmentinbreastcancers
AT guilhembousquet tp53statusandresponsetotreatmentinbreastcancers
AT louisfrancoisplassa tp53statusandresponsetotreatmentinbreastcancers
AT philippebertheau tp53statusandresponsetotreatmentinbreastcancers
AT annejanin tp53statusandresponsetotreatmentinbreastcancers
_version_ 1725250296943214592

Similar Items