Fine needle biopsy of malignant tumors of the liver: a retrospective study of 624 cases from a single institution experience
Abstract Background Liver is one of the most common organs involved by metastatic neoplasms. In addition, a number of primary tumors can arise in the liver. Fine needle biopsy (FNB) is the most commonly used method for diagnosis of liver masses. Not much literature is available during the past 10 ye...
Main Authors: | , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
BMC
2020-05-01
|
Series: | Diagnostic Pathology |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s13000-020-00965-5 |
id |
doaj-eac5cf2fcf8044949d353fefb4c01620 |
---|---|
record_format |
Article |
spelling |
doaj-eac5cf2fcf8044949d353fefb4c016202020-11-25T03:10:25ZengBMCDiagnostic Pathology1746-15962020-05-011511910.1186/s13000-020-00965-5Fine needle biopsy of malignant tumors of the liver: a retrospective study of 624 cases from a single institution experienceLin Zhang0Zhenjian Cai1Joe Rodriguez2Songlin Zhang3Jaiyeola Thomas4Hui Zhu5Department of Pathology and Laboratory Medicine, University of Texas Health Science Center at HoustonDepartment of Pathology and Laboratory Medicine, University of Texas Health Science Center at HoustonDepartment of Pathology and Laboratory Medicine, University of Texas Health Science Center at HoustonDepartment of Pathology and Laboratory Medicine, University of Texas Health Science Center at HoustonDepartment of Pathology and Laboratory Medicine, University of Texas Health Science Center at HoustonDepartment of Pathology and Laboratory Medicine, University of Texas Health Science Center at HoustonAbstract Background Liver is one of the most common organs involved by metastatic neoplasms. In addition, a number of primary tumors can arise in the liver. Fine needle biopsy (FNB) is the most commonly used method for diagnosis of liver masses. Not much literature is available during the past 10 years about FNB of liver tumors. All large studies were performed more than 15 years ago. With the introduction of new disease entities, new tumor classification systems, and new diagnostic methods, updated documentation of FNB of liver neoplasms is much needed. Methods Liver FNB cases that were diagnosed as “Positive for Malignancy” between 2010 and 2018 were retrieved from the cytopathology database in our institution. Patient medical records, cytopathology and surgical pathology reports, and slides from selected cases were retrieved and reviewed. Results Over 30 different types of malignant tumors were identified in 624 malignant FNB cases, with the most common tumors being metastatic colorectal and pancreatic adenocarcinomas. Rare tumors include EBV-positive leiomyosarcoma, mesothelioma, and paraganglioma, among others. A subset of patients presented with widespread metastases involving liver with no known history. Identifying the primary sites in those cases can be challenging. We also found that in our practice, a significant number of hepatocellular carcinoma were diagnosed by FNB in recent years. Conclusions A tremendous variety of neoplasms can occur in liver. Accurate diagnosis is essential for proper patient management. Familiarization with morphological features and judicious usage of ancillary studies are essential for accurate diagnosis.http://link.springer.com/article/10.1186/s13000-020-00965-5Liver metastasesPrimary liver neoplasmsFine-needle biopsy (FNB)Carcinoma of unknown primary (CUP)Hepatocellular carcinoma (HCC) |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Lin Zhang Zhenjian Cai Joe Rodriguez Songlin Zhang Jaiyeola Thomas Hui Zhu |
spellingShingle |
Lin Zhang Zhenjian Cai Joe Rodriguez Songlin Zhang Jaiyeola Thomas Hui Zhu Fine needle biopsy of malignant tumors of the liver: a retrospective study of 624 cases from a single institution experience Diagnostic Pathology Liver metastases Primary liver neoplasms Fine-needle biopsy (FNB) Carcinoma of unknown primary (CUP) Hepatocellular carcinoma (HCC) |
author_facet |
Lin Zhang Zhenjian Cai Joe Rodriguez Songlin Zhang Jaiyeola Thomas Hui Zhu |
author_sort |
Lin Zhang |
title |
Fine needle biopsy of malignant tumors of the liver: a retrospective study of 624 cases from a single institution experience |
title_short |
Fine needle biopsy of malignant tumors of the liver: a retrospective study of 624 cases from a single institution experience |
title_full |
Fine needle biopsy of malignant tumors of the liver: a retrospective study of 624 cases from a single institution experience |
title_fullStr |
Fine needle biopsy of malignant tumors of the liver: a retrospective study of 624 cases from a single institution experience |
title_full_unstemmed |
Fine needle biopsy of malignant tumors of the liver: a retrospective study of 624 cases from a single institution experience |
title_sort |
fine needle biopsy of malignant tumors of the liver: a retrospective study of 624 cases from a single institution experience |
publisher |
BMC |
series |
Diagnostic Pathology |
issn |
1746-1596 |
publishDate |
2020-05-01 |
description |
Abstract Background Liver is one of the most common organs involved by metastatic neoplasms. In addition, a number of primary tumors can arise in the liver. Fine needle biopsy (FNB) is the most commonly used method for diagnosis of liver masses. Not much literature is available during the past 10 years about FNB of liver tumors. All large studies were performed more than 15 years ago. With the introduction of new disease entities, new tumor classification systems, and new diagnostic methods, updated documentation of FNB of liver neoplasms is much needed. Methods Liver FNB cases that were diagnosed as “Positive for Malignancy” between 2010 and 2018 were retrieved from the cytopathology database in our institution. Patient medical records, cytopathology and surgical pathology reports, and slides from selected cases were retrieved and reviewed. Results Over 30 different types of malignant tumors were identified in 624 malignant FNB cases, with the most common tumors being metastatic colorectal and pancreatic adenocarcinomas. Rare tumors include EBV-positive leiomyosarcoma, mesothelioma, and paraganglioma, among others. A subset of patients presented with widespread metastases involving liver with no known history. Identifying the primary sites in those cases can be challenging. We also found that in our practice, a significant number of hepatocellular carcinoma were diagnosed by FNB in recent years. Conclusions A tremendous variety of neoplasms can occur in liver. Accurate diagnosis is essential for proper patient management. Familiarization with morphological features and judicious usage of ancillary studies are essential for accurate diagnosis. |
topic |
Liver metastases Primary liver neoplasms Fine-needle biopsy (FNB) Carcinoma of unknown primary (CUP) Hepatocellular carcinoma (HCC) |
url |
http://link.springer.com/article/10.1186/s13000-020-00965-5 |
work_keys_str_mv |
AT linzhang fineneedlebiopsyofmalignanttumorsoftheliveraretrospectivestudyof624casesfromasingleinstitutionexperience AT zhenjiancai fineneedlebiopsyofmalignanttumorsoftheliveraretrospectivestudyof624casesfromasingleinstitutionexperience AT joerodriguez fineneedlebiopsyofmalignanttumorsoftheliveraretrospectivestudyof624casesfromasingleinstitutionexperience AT songlinzhang fineneedlebiopsyofmalignanttumorsoftheliveraretrospectivestudyof624casesfromasingleinstitutionexperience AT jaiyeolathomas fineneedlebiopsyofmalignanttumorsoftheliveraretrospectivestudyof624casesfromasingleinstitutionexperience AT huizhu fineneedlebiopsyofmalignanttumorsoftheliveraretrospectivestudyof624casesfromasingleinstitutionexperience |
_version_ |
1724658777204981760 |