Two Distinct Genotypes of KPC-2-Producing <i>Klebsiella pneumoniae</i> Isolates from South Korea
In this study, we investigated the characteristics of KPC-2-producing <i>Klebsiella pneumoniae</i> (KP-Kp) isolates from a hospital in South Korea. Among the 37 KP-Kp isolates, two main clones were identified—ST11 and ST307. ST11 isolates showed higher minimum inhibitory concentrations f...
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doaj-ead07c8d9710489bb99dd5a878e233e72021-08-26T13:27:53ZengMDPI AGAntibiotics2079-63822021-07-011091191110.3390/antibiotics10080911Two Distinct Genotypes of KPC-2-Producing <i>Klebsiella pneumoniae</i> Isolates from South KoreaJee Hong Kim0Yun Young Cho1Ji Young Choi2Yu Mi Wi3Kwan Soo Ko4Department of Microbiology, Sungkyunkwan University School of Medicine, Suwon 16419, KoreaDepartment of Microbiology, Sungkyunkwan University School of Medicine, Suwon 16419, KoreaDepartment of Microbiology, Sungkyunkwan University School of Medicine, Suwon 16419, KoreaDivision of Infectious Diseases, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon 51353, KoreaDepartment of Microbiology, Sungkyunkwan University School of Medicine, Suwon 16419, KoreaIn this study, we investigated the characteristics of KPC-2-producing <i>Klebsiella pneumoniae</i> (KP-Kp) isolates from a hospital in South Korea. Among the 37 KP-Kp isolates, two main clones were identified—ST11 and ST307. ST11 isolates showed higher minimum inhibitory concentrations for carbapenems than ST307 isolates. All ST307 isolates were resistant to gentamicin and trimethoprim–sulfamethoxazole, but ST11 isolates were not. However, most tigecycline-resistant or colistin-resistant isolates belonged to ST11. The two KP-Kp clones showed different combinations of <i>wzi</i> and K serotypes. Plasmids from ST11 KP-Kp isolates exhibited diverse incompatibility types. Serum resistance and macrophage infection assays indicated that ST11 may be more virulent than ST307. The changes in the main clones of KP-Kp isolates over time as well as the different characteristics of these clones, including virulence, suggest the need for their continuous monitoring.https://www.mdpi.com/2079-6382/10/8/911carbapenemaseKPC<i>Klebsiella pneumoniae</i> |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jee Hong Kim Yun Young Cho Ji Young Choi Yu Mi Wi Kwan Soo Ko |
spellingShingle |
Jee Hong Kim Yun Young Cho Ji Young Choi Yu Mi Wi Kwan Soo Ko Two Distinct Genotypes of KPC-2-Producing <i>Klebsiella pneumoniae</i> Isolates from South Korea Antibiotics carbapenemase KPC <i>Klebsiella pneumoniae</i> |
author_facet |
Jee Hong Kim Yun Young Cho Ji Young Choi Yu Mi Wi Kwan Soo Ko |
author_sort |
Jee Hong Kim |
title |
Two Distinct Genotypes of KPC-2-Producing <i>Klebsiella pneumoniae</i> Isolates from South Korea |
title_short |
Two Distinct Genotypes of KPC-2-Producing <i>Klebsiella pneumoniae</i> Isolates from South Korea |
title_full |
Two Distinct Genotypes of KPC-2-Producing <i>Klebsiella pneumoniae</i> Isolates from South Korea |
title_fullStr |
Two Distinct Genotypes of KPC-2-Producing <i>Klebsiella pneumoniae</i> Isolates from South Korea |
title_full_unstemmed |
Two Distinct Genotypes of KPC-2-Producing <i>Klebsiella pneumoniae</i> Isolates from South Korea |
title_sort |
two distinct genotypes of kpc-2-producing <i>klebsiella pneumoniae</i> isolates from south korea |
publisher |
MDPI AG |
series |
Antibiotics |
issn |
2079-6382 |
publishDate |
2021-07-01 |
description |
In this study, we investigated the characteristics of KPC-2-producing <i>Klebsiella pneumoniae</i> (KP-Kp) isolates from a hospital in South Korea. Among the 37 KP-Kp isolates, two main clones were identified—ST11 and ST307. ST11 isolates showed higher minimum inhibitory concentrations for carbapenems than ST307 isolates. All ST307 isolates were resistant to gentamicin and trimethoprim–sulfamethoxazole, but ST11 isolates were not. However, most tigecycline-resistant or colistin-resistant isolates belonged to ST11. The two KP-Kp clones showed different combinations of <i>wzi</i> and K serotypes. Plasmids from ST11 KP-Kp isolates exhibited diverse incompatibility types. Serum resistance and macrophage infection assays indicated that ST11 may be more virulent than ST307. The changes in the main clones of KP-Kp isolates over time as well as the different characteristics of these clones, including virulence, suggest the need for their continuous monitoring. |
topic |
carbapenemase KPC <i>Klebsiella pneumoniae</i> |
url |
https://www.mdpi.com/2079-6382/10/8/911 |
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