Intermedin protects against sepsis by concurrently re-establishing the endothelial barrier and alleviating inflammatory responses
Sepsis is a life-threatening condition. Here, the authors show that intermedin alleviates organ injury and decreases mortality in septic mice by concurrently alleviating vascular leakage and inflammatory responses. Patients with high intermedin levels exhibit a low risk of shock, lower severity scor...
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Nature Publishing Group
2018-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-05062-2 |
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doaj-ead986329bea46afb1f74f0ac772d5502021-05-11T10:19:39ZengNature Publishing GroupNature Communications2041-17232018-07-019111510.1038/s41467-018-05062-2Intermedin protects against sepsis by concurrently re-establishing the endothelial barrier and alleviating inflammatory responsesFei Xiao0Denian Wang1Lingmiao Kong2Min Li3Zhongxue Feng4Bingxing Shuai5Lijun Wang6Yong’gang Wei7Hongyu Li8Sisi Wu9Chun Tan10Huan Zhao11Xuejiao Hu12Jin Liu13Yan Kang14Xuelian Liao15Yan Zhou16Wei Zhang17Molecular Medicine Research Center, State Key Laboratory of Biotherapy/Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan UniversityMolecular Medicine Research Center, State Key Laboratory of Biotherapy/Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan UniversityMolecular Medicine Research Center, State Key Laboratory of Biotherapy/Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan UniversityMolecular Medicine Research Center, State Key Laboratory of Biotherapy/Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan UniversityMolecular Medicine Research Center, State Key Laboratory of Biotherapy/Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan UniversityDepartment of Intensive Care Unit, West China Hospital, Sichuan UniversityMolecular Medicine Research Center, State Key Laboratory of Biotherapy/Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan UniversityDepartment of Liver Surgery, West China Hospital, Sichuan UniversityDepartment of Liver Surgery, West China Hospital, Sichuan UniversityMolecular Medicine Research Center, State Key Laboratory of Biotherapy/Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan UniversityMolecular Medicine Research Center, State Key Laboratory of Biotherapy/Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan UniversityMolecular Medicine Research Center, State Key Laboratory of Biotherapy/Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan UniversityDepartment of Laboratory Medicine, West China Hospital, Sichuan UniversityDepartment of Anesthesiology, West China Hospital, Sichuan UniversityDepartment of Intensive Care Unit, West China Hospital, Sichuan UniversityDepartment of Intensive Care Unit, West China Hospital, Sichuan UniversityDepartment of Intensive Care Unit, West China Hospital, Sichuan UniversityMolecular Medicine Research Center, State Key Laboratory of Biotherapy/Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan UniversitySepsis is a life-threatening condition. Here, the authors show that intermedin alleviates organ injury and decreases mortality in septic mice by concurrently alleviating vascular leakage and inflammatory responses. Patients with high intermedin levels exhibit a low risk of shock, lower severity scores, and greatly improved survival outcomes.https://doi.org/10.1038/s41467-018-05062-2 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Fei Xiao Denian Wang Lingmiao Kong Min Li Zhongxue Feng Bingxing Shuai Lijun Wang Yong’gang Wei Hongyu Li Sisi Wu Chun Tan Huan Zhao Xuejiao Hu Jin Liu Yan Kang Xuelian Liao Yan Zhou Wei Zhang |
| spellingShingle |
Fei Xiao Denian Wang Lingmiao Kong Min Li Zhongxue Feng Bingxing Shuai Lijun Wang Yong’gang Wei Hongyu Li Sisi Wu Chun Tan Huan Zhao Xuejiao Hu Jin Liu Yan Kang Xuelian Liao Yan Zhou Wei Zhang Intermedin protects against sepsis by concurrently re-establishing the endothelial barrier and alleviating inflammatory responses Nature Communications |
| author_facet |
Fei Xiao Denian Wang Lingmiao Kong Min Li Zhongxue Feng Bingxing Shuai Lijun Wang Yong’gang Wei Hongyu Li Sisi Wu Chun Tan Huan Zhao Xuejiao Hu Jin Liu Yan Kang Xuelian Liao Yan Zhou Wei Zhang |
| author_sort |
Fei Xiao |
| title |
Intermedin protects against sepsis by concurrently re-establishing the endothelial barrier and alleviating inflammatory responses |
| title_short |
Intermedin protects against sepsis by concurrently re-establishing the endothelial barrier and alleviating inflammatory responses |
| title_full |
Intermedin protects against sepsis by concurrently re-establishing the endothelial barrier and alleviating inflammatory responses |
| title_fullStr |
Intermedin protects against sepsis by concurrently re-establishing the endothelial barrier and alleviating inflammatory responses |
| title_full_unstemmed |
Intermedin protects against sepsis by concurrently re-establishing the endothelial barrier and alleviating inflammatory responses |
| title_sort |
intermedin protects against sepsis by concurrently re-establishing the endothelial barrier and alleviating inflammatory responses |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2018-07-01 |
| description |
Sepsis is a life-threatening condition. Here, the authors show that intermedin alleviates organ injury and decreases mortality in septic mice by concurrently alleviating vascular leakage and inflammatory responses. Patients with high intermedin levels exhibit a low risk of shock, lower severity scores, and greatly improved survival outcomes. |
| url |
https://doi.org/10.1038/s41467-018-05062-2 |
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