Idiosyncratic reaction to single 7.5 mg dose of methotrexate: Mishappening by chance

• Main Authors: Pallavi Kumari, Sonia Jain, Pratiksha Sonkusale
• Format: Article
• Language: English
• Published: Wolters Kluwer Medknow Publications 2021-01-01
• Series: CHRISMED Journal of Health and Research
• Subjects: idiosyncratic reaction; psoriasis; tablet methotrexate
• Online Access: http://www.cjhr.org/article.asp?issn=2348-3334;year=2021;volume=8;issue=1;spage=50;epage=51;aulast=Kumari

Methotrexate (MTX) is one of the most common systemic immunosuppressive agents prescribed in dermatology. MTX toxicity targets skin, gastrointestinal mucosa, kidney, liver, and bone marrow. Toxic effects of MTX presenting as hepatic, renal, pulmonary, and bone marrow disorders occur less frequently than the minor effects but may be life-threatening. Characteristic signs and symptoms of acute MTX toxicity are based on extent and severity of organ involvement. Here, we report a 55-year-old married male, known case of chronic plaque-type psoriasis presenting with reaction to single dose of tablet MTX 7.5 mg as advised by the dermatologist for his disease. On history and clinical examination, diagnosis of idiosyncratic reaction to single dose of tablet MTX 7.5 mg was made.