Assessment of Diabetic Autonomic Nervous Dysfunction with a Novel Percussion Entropy Approach
This study investigated the validity of a novel parameter, percussion entropy index (PEI), for assessing baroreflex sensitivity. PEI was acquired through comparing the similarity in tendency of change between the amplitudes of successive digital volume pulse (DVP) signals and changes in R-R interval...
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doaj-eae24751daf2471e8ce159f6439acbc62020-11-25T01:11:10ZengHindawi-WileyComplexity1076-27871099-05262019-01-01201910.1155/2019/64698536469853Assessment of Diabetic Autonomic Nervous Dysfunction with a Novel Percussion Entropy ApproachHai-Cheng Wei0Ming-Xia Xiao1Na Ta2Hsien-Tsai Wu3Cheuk-Kwan Sun4School of Electrical and Information Engineering, North Minzu University, No. 204 North – Wenchang St., Xixia District, Yinchuan, Ningxia 750021, ChinaSchool of Electrical and Information Engineering, North Minzu University, No. 204 North – Wenchang St., Xixia District, Yinchuan, Ningxia 750021, ChinaSchool of Electrical and Information Engineering, North Minzu University, No. 204 North – Wenchang St., Xixia District, Yinchuan, Ningxia 750021, ChinaDepartment of Electrical Engineering, National Dong Hwa University, No. 1, Sec. 2, Da Hsueh Rd., Shoufeng, Hualien 97401, TaiwanDepartment of Emergency Medicine, E-Da Hospital, I-Shou University School of Medicine for International Students, No. 1, Yida Road, Jiaosu Village, Yanchao District, Kaohsiung City 82445, TaiwanThis study investigated the validity of a novel parameter, percussion entropy index (PEI), for assessing baroreflex sensitivity. PEI was acquired through comparing the similarity in tendency of change between the amplitudes of successive digital volume pulse (DVP) signals and changes in R-R intervals (RRI) of successive cardiac cycles. Totally 108 upper middle-aged volunteers were divided into three groups: healthy subjects (Group 1, age 41–80, n=41), those with well-controlled type 2 diabetes mellitus (T2DM) (Group 2, age 41–82, n=36, glycated hemoglobin (HbA1c)<6.5%), and patients with poorly controlled T2DM (Group 3, age 44–77, n=31, HbA1c≧6.5%). Percussion entropy index (PEI) was computed from DVP signals acquired through photoplethysmography (PPG) and RRI from electrocardiogram in 1000 successive cardiac cycles for each subject. Autonomic function was also assessed by Poincaré index (SD1/SD2 ratio, SSR), low- to high-frequency power ratio (LFP/HFP, LHR), and small-scale multiscale entropy index (MEISS) for comparison. Demographic, anthropometric, hemodynamic, and serum biochemical parameters of all testing subjects were obtained for investigating the significance of associations with the three parameters. The results showed that MEISS and PEI successfully discriminated among the three groups (p<0.017). However, only PEI showed significant associations with indicators of both acute (i.e., fasting blood sugar concentration, p<0.017) and chronic (i.e., HbA1c level, p<0.001) blood sugar control. Multivariate analysis also showed significant associations of PEI with fasting blood sugar and HbA1c levels in all subjects. The interpreting effect of the two independent variables, HbA1c level and fasting blood sugar concentration, on PEI was 71.4% and 12.3%, respectively. In conclusion, the results demonstrated that additional information on diabetic autonomic dysfunction can be obtained through comparing two simultaneously acquired physiological time series. The significant associations of percussion entropy index with indicators of blood sugar control also highlight its possible role in early screening of the disease.http://dx.doi.org/10.1155/2019/6469853 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hai-Cheng Wei Ming-Xia Xiao Na Ta Hsien-Tsai Wu Cheuk-Kwan Sun |
spellingShingle |
Hai-Cheng Wei Ming-Xia Xiao Na Ta Hsien-Tsai Wu Cheuk-Kwan Sun Assessment of Diabetic Autonomic Nervous Dysfunction with a Novel Percussion Entropy Approach Complexity |
author_facet |
Hai-Cheng Wei Ming-Xia Xiao Na Ta Hsien-Tsai Wu Cheuk-Kwan Sun |
author_sort |
Hai-Cheng Wei |
title |
Assessment of Diabetic Autonomic Nervous Dysfunction with a Novel Percussion Entropy Approach |
title_short |
Assessment of Diabetic Autonomic Nervous Dysfunction with a Novel Percussion Entropy Approach |
title_full |
Assessment of Diabetic Autonomic Nervous Dysfunction with a Novel Percussion Entropy Approach |
title_fullStr |
Assessment of Diabetic Autonomic Nervous Dysfunction with a Novel Percussion Entropy Approach |
title_full_unstemmed |
Assessment of Diabetic Autonomic Nervous Dysfunction with a Novel Percussion Entropy Approach |
title_sort |
assessment of diabetic autonomic nervous dysfunction with a novel percussion entropy approach |
publisher |
Hindawi-Wiley |
series |
Complexity |
issn |
1076-2787 1099-0526 |
publishDate |
2019-01-01 |
description |
This study investigated the validity of a novel parameter, percussion entropy index (PEI), for assessing baroreflex sensitivity. PEI was acquired through comparing the similarity in tendency of change between the amplitudes of successive digital volume pulse (DVP) signals and changes in R-R intervals (RRI) of successive cardiac cycles. Totally 108 upper middle-aged volunteers were divided into three groups: healthy subjects (Group 1, age 41–80, n=41), those with well-controlled type 2 diabetes mellitus (T2DM) (Group 2, age 41–82, n=36, glycated hemoglobin (HbA1c)<6.5%), and patients with poorly controlled T2DM (Group 3, age 44–77, n=31, HbA1c≧6.5%). Percussion entropy index (PEI) was computed from DVP signals acquired through photoplethysmography (PPG) and RRI from electrocardiogram in 1000 successive cardiac cycles for each subject. Autonomic function was also assessed by Poincaré index (SD1/SD2 ratio, SSR), low- to high-frequency power ratio (LFP/HFP, LHR), and small-scale multiscale entropy index (MEISS) for comparison. Demographic, anthropometric, hemodynamic, and serum biochemical parameters of all testing subjects were obtained for investigating the significance of associations with the three parameters. The results showed that MEISS and PEI successfully discriminated among the three groups (p<0.017). However, only PEI showed significant associations with indicators of both acute (i.e., fasting blood sugar concentration, p<0.017) and chronic (i.e., HbA1c level, p<0.001) blood sugar control. Multivariate analysis also showed significant associations of PEI with fasting blood sugar and HbA1c levels in all subjects. The interpreting effect of the two independent variables, HbA1c level and fasting blood sugar concentration, on PEI was 71.4% and 12.3%, respectively. In conclusion, the results demonstrated that additional information on diabetic autonomic dysfunction can be obtained through comparing two simultaneously acquired physiological time series. The significant associations of percussion entropy index with indicators of blood sugar control also highlight its possible role in early screening of the disease. |
url |
http://dx.doi.org/10.1155/2019/6469853 |
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