Anti-inflammatory and anti-nociceptive effects of hydroalchoholic extract of Nepeta menthoides on pain in aerial parts in male mice

• Main Authors: Sosan Asadi Balsin Sharif Abadi1, Sima Nasri, Gholamreza Amin, Sayeh Bidaran
• Format: Article
• Language: fas
• Published: Jahrom University of Medical Sciences 2013-07-01
• Series: فصلنامه دانشگاه علوم پزشکی جهرم
• Subjects: analgesics; plant extracts; mice
• Online Access: http://jmj.jums.ac.ir/article-1-252-en.html

Introduction: The application of herbal plants instead of synthetic drugs has been increasing in recent years because of their lower side-effects and high varieties of efficient components. An investigation on anti-nociceptive and anti-inflammatory effects of hydroalcoholic extract of Nepeta menthoides seems to be necessary due to the existence of its components. Materials and Methods: This study was done on 224 NMRI male mice weighing 20-25 g. Xylene-induced ear edema and Formalin test were used for demonstrating its anti-inflammatory and anti-nociceptive effects. Results: The hydroalcholic extract had no toxic effect. This study showed that Nepeta menthoides aerial parts have anti-inflammatory effect at all doses, particularly at dose of 2800 mg/kg and significantly decreased nociception in chronic phases. The dose of 2800 mg/kg had the most anti-nociceptive effect in chronic phases. Meanwhile, in the immersion test, nociception decreased at a dose of 1400 mg/kg significantly. Conclusion: Hydroalcoholic extract of Nepeta menthoides has anti-nociceptive and anti-inflammatory effects. These effects might be due to its Nepetalactone and 1,8 cineole components.