A Quantitative Pharmacology Model of Exosome-Mediated Drug Efflux and Perturbation-Induced Synergy

A Quantitative Pharmacology Model of Exosome-Mediated Drug Efflux and Perturbation-Induced Synergy

Exosomes, naturally occurring vesicles secreted by cells, are undergoing development as drug carriers. We used experimental and computational studies to investigate the kinetics of intracellular exosome processing and exosome-mediated drug efflux and the effects of exosome inhibition. The experiment...

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Bibliographic Details
Main Authors: Jin Wang, Bertrand Z. Yeung, M. Guillaume Wientjes, Minjian Cui, Cody J. Peer, Ze Lu, William D. Figg, Sukyung Woo, Jessie L.-S. Au
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Pharmaceutics
Subjects:
quantitative pharmacology model
exosome-mediated drug efflux
chemosensitization mechanism
Online Access:https://www.mdpi.com/1999-4923/13/7/997

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