The Role of Epigenetics in Arterial Calcification

Arterial calcification is highly prevalent and correlated with cardiovascular mortality, especially in patients with ESRD or diabetes. The pathogenesis of arterial calcification is multifactorial, with both genetic and environmental factors being implicated. In recent years, several mechanisms contr...

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Main Authors: Shan-Shan Wu, Xiao Lin, Ling-Qing Yuan, Er-Yuan Liao
Format: Article
Language:English
Published: Hindawi Limited 2015-01-01
Series:BioMed Research International
Online Access:http://dx.doi.org/10.1155/2015/320849
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spelling doaj-eafcedc5c03345e48ba089a401eee8d92020-11-24T23:58:11ZengHindawi LimitedBioMed Research International2314-61332314-61412015-01-01201510.1155/2015/320849320849The Role of Epigenetics in Arterial CalcificationShan-Shan Wu0Xiao Lin1Ling-Qing Yuan2Er-Yuan Liao3Endocrinology Department, Pingxiang People’s Hospital, 128 Anyuan Area Square Road, Pingxiang, Jiangxi 337000, ChinaInstitute of Metabolism and Endocrinology, The Second Xiangya Hospital, Central South University, 139 Middle Renmin Road, Changsha, Hunan 410011, ChinaInstitute of Metabolism and Endocrinology, The Second Xiangya Hospital, Central South University, 139 Middle Renmin Road, Changsha, Hunan 410011, ChinaInstitute of Metabolism and Endocrinology, The Second Xiangya Hospital, Central South University, 139 Middle Renmin Road, Changsha, Hunan 410011, ChinaArterial calcification is highly prevalent and correlated with cardiovascular mortality, especially in patients with ESRD or diabetes. The pathogenesis of arterial calcification is multifactorial, with both genetic and environmental factors being implicated. In recent years, several mechanisms contributing to arterial calcification have been proposed. However, these can only explain a small proportion of the variability in arterial calcification, which is a major obstacle for its prevention and management. Epigenetics has emerged as one of the most promising areas that may fill in some of the gaps in our current knowledge of the interaction between the environmental insults with gene regulation in the development of diseases. Epigenetics refers to heritable and acquired changes in gene transcription that occur independently of the DNA sequence. Well-known components of epigenetic regulation include DNA methylation, histone modifications, and microRNAs. Epigenetics research in the regulation of arterial calcification has only recently been elucidated. In this review, we will summarise recent progress in epigenetic pathways involved in arterial calcification and discuss potential therapeutic interventions based on epigenetic mechanisms.http://dx.doi.org/10.1155/2015/320849
collection DOAJ
language English
format Article
sources DOAJ
author Shan-Shan Wu
Xiao Lin
Ling-Qing Yuan
Er-Yuan Liao
spellingShingle Shan-Shan Wu
Xiao Lin
Ling-Qing Yuan
Er-Yuan Liao
The Role of Epigenetics in Arterial Calcification
BioMed Research International
author_facet Shan-Shan Wu
Xiao Lin
Ling-Qing Yuan
Er-Yuan Liao
author_sort Shan-Shan Wu
title The Role of Epigenetics in Arterial Calcification
title_short The Role of Epigenetics in Arterial Calcification
title_full The Role of Epigenetics in Arterial Calcification
title_fullStr The Role of Epigenetics in Arterial Calcification
title_full_unstemmed The Role of Epigenetics in Arterial Calcification
title_sort role of epigenetics in arterial calcification
publisher Hindawi Limited
series BioMed Research International
issn 2314-6133
2314-6141
publishDate 2015-01-01
description Arterial calcification is highly prevalent and correlated with cardiovascular mortality, especially in patients with ESRD or diabetes. The pathogenesis of arterial calcification is multifactorial, with both genetic and environmental factors being implicated. In recent years, several mechanisms contributing to arterial calcification have been proposed. However, these can only explain a small proportion of the variability in arterial calcification, which is a major obstacle for its prevention and management. Epigenetics has emerged as one of the most promising areas that may fill in some of the gaps in our current knowledge of the interaction between the environmental insults with gene regulation in the development of diseases. Epigenetics refers to heritable and acquired changes in gene transcription that occur independently of the DNA sequence. Well-known components of epigenetic regulation include DNA methylation, histone modifications, and microRNAs. Epigenetics research in the regulation of arterial calcification has only recently been elucidated. In this review, we will summarise recent progress in epigenetic pathways involved in arterial calcification and discuss potential therapeutic interventions based on epigenetic mechanisms.
url http://dx.doi.org/10.1155/2015/320849
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