The Role of Epigenetics in Arterial Calcification
Arterial calcification is highly prevalent and correlated with cardiovascular mortality, especially in patients with ESRD or diabetes. The pathogenesis of arterial calcification is multifactorial, with both genetic and environmental factors being implicated. In recent years, several mechanisms contr...
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doaj-eafcedc5c03345e48ba089a401eee8d92020-11-24T23:58:11ZengHindawi LimitedBioMed Research International2314-61332314-61412015-01-01201510.1155/2015/320849320849The Role of Epigenetics in Arterial CalcificationShan-Shan Wu0Xiao Lin1Ling-Qing Yuan2Er-Yuan Liao3Endocrinology Department, Pingxiang People’s Hospital, 128 Anyuan Area Square Road, Pingxiang, Jiangxi 337000, ChinaInstitute of Metabolism and Endocrinology, The Second Xiangya Hospital, Central South University, 139 Middle Renmin Road, Changsha, Hunan 410011, ChinaInstitute of Metabolism and Endocrinology, The Second Xiangya Hospital, Central South University, 139 Middle Renmin Road, Changsha, Hunan 410011, ChinaInstitute of Metabolism and Endocrinology, The Second Xiangya Hospital, Central South University, 139 Middle Renmin Road, Changsha, Hunan 410011, ChinaArterial calcification is highly prevalent and correlated with cardiovascular mortality, especially in patients with ESRD or diabetes. The pathogenesis of arterial calcification is multifactorial, with both genetic and environmental factors being implicated. In recent years, several mechanisms contributing to arterial calcification have been proposed. However, these can only explain a small proportion of the variability in arterial calcification, which is a major obstacle for its prevention and management. Epigenetics has emerged as one of the most promising areas that may fill in some of the gaps in our current knowledge of the interaction between the environmental insults with gene regulation in the development of diseases. Epigenetics refers to heritable and acquired changes in gene transcription that occur independently of the DNA sequence. Well-known components of epigenetic regulation include DNA methylation, histone modifications, and microRNAs. Epigenetics research in the regulation of arterial calcification has only recently been elucidated. In this review, we will summarise recent progress in epigenetic pathways involved in arterial calcification and discuss potential therapeutic interventions based on epigenetic mechanisms.http://dx.doi.org/10.1155/2015/320849 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Shan-Shan Wu Xiao Lin Ling-Qing Yuan Er-Yuan Liao |
spellingShingle |
Shan-Shan Wu Xiao Lin Ling-Qing Yuan Er-Yuan Liao The Role of Epigenetics in Arterial Calcification BioMed Research International |
author_facet |
Shan-Shan Wu Xiao Lin Ling-Qing Yuan Er-Yuan Liao |
author_sort |
Shan-Shan Wu |
title |
The Role of Epigenetics in Arterial Calcification |
title_short |
The Role of Epigenetics in Arterial Calcification |
title_full |
The Role of Epigenetics in Arterial Calcification |
title_fullStr |
The Role of Epigenetics in Arterial Calcification |
title_full_unstemmed |
The Role of Epigenetics in Arterial Calcification |
title_sort |
role of epigenetics in arterial calcification |
publisher |
Hindawi Limited |
series |
BioMed Research International |
issn |
2314-6133 2314-6141 |
publishDate |
2015-01-01 |
description |
Arterial calcification is highly prevalent and correlated with cardiovascular mortality, especially in patients with ESRD or diabetes. The pathogenesis of arterial calcification is multifactorial, with both genetic and environmental factors being implicated. In recent years, several mechanisms contributing to arterial calcification have been proposed. However, these can only explain a small proportion of the variability in arterial calcification, which is a major obstacle for its prevention and management. Epigenetics has emerged as one of the most promising areas that may fill in some of the gaps in our current knowledge of the interaction between the environmental insults with gene regulation in the development of diseases. Epigenetics refers to heritable and acquired changes in gene transcription that occur independently of the DNA sequence. Well-known components of epigenetic regulation include DNA methylation, histone modifications, and microRNAs. Epigenetics research in the regulation of arterial calcification has only recently been elucidated. In this review, we will summarise recent progress in epigenetic pathways involved in arterial calcification and discuss potential therapeutic interventions based on epigenetic mechanisms. |
url |
http://dx.doi.org/10.1155/2015/320849 |
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