Identification of HIV transmitting CD11c+ human epidermal dendritic cells

Identification of HIV transmitting CD11c+ human epidermal dendritic cells

Composition and function of immune populations at barrier surfaces is crucial for response to infection. Here, the authors identify a population of dendritic cells in human epidermis, abundant in anogenital epithelia and distinct from Langerhans cells by surface phenotype and by high capacity for HI...

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Main Authors: Kirstie M. Bertram, Rachel A. Botting, Heeva Baharlou, Jake W. Rhodes, Hafsa Rana, J. Dinny Graham, Ellis Patrick, James Fletcher, Toby M. Plasto, Naomi R. Truong, Caroline Royle, Chloe M. Doyle, Orion Tong, Najla Nasr, Laith Barnouti, Mark P. Kohout, Andrew J. Brooks, Michael P. Wines, Peter Haertsch, Jake Lim, Martijn P. Gosselink, Grahame Ctercteko, Jacob D. Estes, Melissa J. Churchill, Paul U. Cameron, Eric Hunter, Muzlifah A. Haniffa, Anthony L. Cunningham, Andrew N. Harman
Format: Article
Language:English
Published: Nature Publishing Group 2019-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-10697-w
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spelling doaj-eb12f23a92dd489b8e91e926a319cbf12021-05-11T11:30:27ZengNature Publishing GroupNature Communications2041-17232019-06-0110111510.1038/s41467-019-10697-wIdentification of HIV transmitting CD11c+ human epidermal dendritic cellsKirstie M. Bertram0Rachel A. Botting1Heeva Baharlou2Jake W. Rhodes3Hafsa Rana4J. Dinny Graham5Ellis Patrick6James Fletcher7Toby M. Plasto8Naomi R. Truong9Caroline Royle10Chloe M. Doyle11Orion Tong12Najla Nasr13Laith Barnouti14Mark P. Kohout15Andrew J. Brooks16Michael P. Wines17Peter Haertsch18Jake Lim19Martijn P. Gosselink20Grahame Ctercteko21Jacob D. Estes22Melissa J. Churchill23Paul U. Cameron24Eric Hunter25Muzlifah A. Haniffa26Anthony L. Cunningham27Andrew N. Harman28Centre for Virus Research, The Westmead Institute for Medical ResearchCentre for Virus Research, The Westmead Institute for Medical ResearchCentre for Virus Research, The Westmead Institute for Medical ResearchCentre for Virus Research, The Westmead Institute for Medical ResearchCentre for Virus Research, The Westmead Institute for Medical ResearchCentre for Virus Research, The Westmead Institute for Medical ResearchCentre for Virus Research, The Westmead Institute for Medical ResearchInstitute of Cellular Medicine, Newcastle UniversityCentre for Virus Research, The Westmead Institute for Medical ResearchCentre for Virus Research, The Westmead Institute for Medical ResearchCentre for Virus Research, The Westmead Institute for Medical ResearchCentre for Virus Research, The Westmead Institute for Medical ResearchCentre for Virus Research, The Westmead Institute for Medical ResearchCentre for Virus Research, The Westmead Institute for Medical ResearchAustralia Plastic SurgeryAustralia Plastic SurgeryWestmead HospitalRoyal North Shore HospitalBurns Unit, Concord Repatriation General HospitalDr Jake Lim PLCCentre for Virus Research, The Westmead Institute for Medical ResearchCentre for Virus Research, The Westmead Institute for Medical ResearchAIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research IncSchool of Health and Biomedical Sciences, College of Science, Engineering and Health, RMIT UniversityThe Peter Doherty Institute for Infection and ImmunityEmory Vaccine CenterInstitute of Cellular Medicine, Newcastle UniversityCentre for Virus Research, The Westmead Institute for Medical ResearchCentre for Virus Research, The Westmead Institute for Medical ResearchComposition and function of immune populations at barrier surfaces is crucial for response to infection. Here, the authors identify a population of dendritic cells in human epidermis, abundant in anogenital epithelia and distinct from Langerhans cells by surface phenotype and by high capacity for HIV infection and transmission.https://doi.org/10.1038/s41467-019-10697-w
collection DOAJ
language English
format Article
sources DOAJ
author Kirstie M. Bertram
Rachel A. Botting
Heeva Baharlou
Jake W. Rhodes
Hafsa Rana
J. Dinny Graham
Ellis Patrick
James Fletcher
Toby M. Plasto
Naomi R. Truong
Caroline Royle
Chloe M. Doyle
Orion Tong
Najla Nasr
Laith Barnouti
Mark P. Kohout
Andrew J. Brooks
Michael P. Wines
Peter Haertsch
Jake Lim
Martijn P. Gosselink
Grahame Ctercteko
Jacob D. Estes
Melissa J. Churchill
Paul U. Cameron
Eric Hunter
Muzlifah A. Haniffa
Anthony L. Cunningham
Andrew N. Harman
spellingShingle Kirstie M. Bertram
Rachel A. Botting
Heeva Baharlou
Jake W. Rhodes
Hafsa Rana
J. Dinny Graham
Ellis Patrick
James Fletcher
Toby M. Plasto
Naomi R. Truong
Caroline Royle
Chloe M. Doyle
Orion Tong
Najla Nasr
Laith Barnouti
Mark P. Kohout
Andrew J. Brooks
Michael P. Wines
Peter Haertsch
Jake Lim
Martijn P. Gosselink
Grahame Ctercteko
Jacob D. Estes
Melissa J. Churchill
Paul U. Cameron
Eric Hunter
Muzlifah A. Haniffa
Anthony L. Cunningham
Andrew N. Harman
Identification of HIV transmitting CD11c+ human epidermal dendritic cells
Nature Communications
author_facet Kirstie M. Bertram
Rachel A. Botting
Heeva Baharlou
Jake W. Rhodes
Hafsa Rana
J. Dinny Graham
Ellis Patrick
James Fletcher
Toby M. Plasto
Naomi R. Truong
Caroline Royle
Chloe M. Doyle
Orion Tong
Najla Nasr
Laith Barnouti
Mark P. Kohout
Andrew J. Brooks
Michael P. Wines
Peter Haertsch
Jake Lim
Martijn P. Gosselink
Grahame Ctercteko
Jacob D. Estes
Melissa J. Churchill
Paul U. Cameron
Eric Hunter
Muzlifah A. Haniffa
Anthony L. Cunningham
Andrew N. Harman
author_sort Kirstie M. Bertram
title Identification of HIV transmitting CD11c+ human epidermal dendritic cells
title_short Identification of HIV transmitting CD11c+ human epidermal dendritic cells
title_full Identification of HIV transmitting CD11c+ human epidermal dendritic cells
title_fullStr Identification of HIV transmitting CD11c+ human epidermal dendritic cells
title_full_unstemmed Identification of HIV transmitting CD11c+ human epidermal dendritic cells
title_sort identification of hiv transmitting cd11c+ human epidermal dendritic cells
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2019-06-01
description Composition and function of immune populations at barrier surfaces is crucial for response to infection. Here, the authors identify a population of dendritic cells in human epidermis, abundant in anogenital epithelia and distinct from Langerhans cells by surface phenotype and by high capacity for HIV infection and transmission.
url https://doi.org/10.1038/s41467-019-10697-w
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