Total and Free Serum Sialic Acid Concentration in Liver Diseases
Background. The objective of this study was to compare the levels of total (TSA) and free (FSA) sialic acid in acute and chronic liver diseases. Materials and Methods. The serum TSA and FSA levels were determined in 278 patients suffering from acute and chronic liver diseases of different etiologies...
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Online Access: | http://dx.doi.org/10.1155/2014/876096 |
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doaj-eb144a5f81734ce8a748feb3d219a6672020-11-24T20:52:16ZengHindawi LimitedBioMed Research International2314-61332314-61412014-01-01201410.1155/2014/876096876096Total and Free Serum Sialic Acid Concentration in Liver DiseasesEwa Gruszewska0Bogdan Cylwik1Anatol Panasiuk2Maciej Szmitkowski3Robert Flisiak4Lech Chrostek5Department of Biochemical Diagnostics, Medical University of Bialystok, Waszyngtona 15A Street, 15-269 Bialystok, PolandDepartment of Pediatric Laboratory Diagnostics, Medical University of Bialystok, Waszyngtona 17 Street, 15-269 Bialystok, PolandDepartment of Infectious Diseases and Hepatology, Medical University of Bialystok, Zurawia 15 Street, 15-540 Bialystok, PolandDepartment of Biochemical Diagnostics, Medical University of Bialystok, Waszyngtona 15A Street, 15-269 Bialystok, PolandDepartment of Infectious Diseases and Hepatology, Medical University of Bialystok, Zurawia 15 Street, 15-540 Bialystok, PolandDepartment of Biochemical Diagnostics, Medical University of Bialystok, Waszyngtona 15A Street, 15-269 Bialystok, PolandBackground. The objective of this study was to compare the levels of total (TSA) and free (FSA) sialic acid in acute and chronic liver diseases. Materials and Methods. The serum TSA and FSA levels were determined in 278 patients suffering from acute and chronic liver diseases of different etiologies. TSA was estimated by enzymatic method and FSA by the thiobarbituric method modified by Skoza and Mohos. Results. There were no significant differences in the serum TSA concentration between liver diseases of different etiologies, although in most of the liver diseases the mean TSA level was significantly lower than that in the control group. In contrast to TSA, the concentration of FSA appears to differ between liver diseases. In toxic hepatitis it was higher than that in nonalcoholic cirrhosis. However, neither of them differs between alcoholic and nonalcoholic cirrhosis or between liver tumors and tumors with cirrhosis. Conclusions. We conclude that the changes in concentrations of TSA and FSA during the same liver diseases indicate significant disturbances in sialylation of serum glycoproteins.http://dx.doi.org/10.1155/2014/876096 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ewa Gruszewska Bogdan Cylwik Anatol Panasiuk Maciej Szmitkowski Robert Flisiak Lech Chrostek |
spellingShingle |
Ewa Gruszewska Bogdan Cylwik Anatol Panasiuk Maciej Szmitkowski Robert Flisiak Lech Chrostek Total and Free Serum Sialic Acid Concentration in Liver Diseases BioMed Research International |
author_facet |
Ewa Gruszewska Bogdan Cylwik Anatol Panasiuk Maciej Szmitkowski Robert Flisiak Lech Chrostek |
author_sort |
Ewa Gruszewska |
title |
Total and Free Serum Sialic Acid Concentration in Liver Diseases |
title_short |
Total and Free Serum Sialic Acid Concentration in Liver Diseases |
title_full |
Total and Free Serum Sialic Acid Concentration in Liver Diseases |
title_fullStr |
Total and Free Serum Sialic Acid Concentration in Liver Diseases |
title_full_unstemmed |
Total and Free Serum Sialic Acid Concentration in Liver Diseases |
title_sort |
total and free serum sialic acid concentration in liver diseases |
publisher |
Hindawi Limited |
series |
BioMed Research International |
issn |
2314-6133 2314-6141 |
publishDate |
2014-01-01 |
description |
Background. The objective of this study was to compare the levels of total (TSA) and free (FSA) sialic acid in acute and chronic liver diseases. Materials and Methods. The serum TSA and FSA levels were determined in 278 patients suffering from acute and chronic liver diseases of different etiologies. TSA was estimated by enzymatic method and FSA by the thiobarbituric method modified by Skoza and Mohos. Results. There were no significant differences in the serum TSA concentration between liver diseases of different etiologies, although in most of the liver diseases the mean TSA level was significantly lower than that in the control group. In contrast to TSA, the concentration of FSA appears to differ between liver diseases. In toxic hepatitis it was higher than that in nonalcoholic cirrhosis. However, neither of them differs between alcoholic and nonalcoholic cirrhosis or between liver tumors and tumors with cirrhosis. Conclusions. We conclude that the changes in concentrations of TSA and FSA during the same liver diseases indicate significant disturbances in sialylation of serum glycoproteins. |
url |
http://dx.doi.org/10.1155/2014/876096 |
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