CD8+ T-Cell Repertoire in Human Leukocyte Antigen Class I-Mismatched Alloreactive Immune Response

CD8+ T-Cell Repertoire in Human Leukocyte Antigen Class I-Mismatched Alloreactive Immune Response

In transplantation, direct allorecognition is a complex interplay between T-cell receptors (TCR) and HLA molecules and their bound peptides expressed on antigen-presenting cells. In analogy to HLA mismatched hematopoietic stem cell transplantation (HSCT), the TCR CDR3β repertoires of alloreactive cy...

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Bibliographic Details
Main Authors: Florence Bettens, Zuleika Calderin Sollet, Stéphane Buhler, Jean Villard
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Immunology
Subjects:
T-cell alloreactivity
human leukocyte antigen (HLA)
T-cell repertoire
T-cell receptor
hematopoietic stem cell transplantation (HSCT)
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.588741/full

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