Effectiveness of naltrexone treatment for alcohol use disorders in HIV: a systematic review
Abstract Background Because alcohol use disorders (AUDs) in patients living with HIV/AIDS are associated with a reduction in therapeutic outcomes and increases the risk of morbidity/mortality, finding an appropriate pharmacotherapy treatment for this disorder is necessary. Objectives This systematic...
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doaj-eb192b9e7c504de09c709e3311d7137e2020-11-25T02:31:44ZengBMCSubstance Abuse Treatment, Prevention, and Policy1747-597X2020-03-011511710.1186/s13011-020-00266-6Effectiveness of naltrexone treatment for alcohol use disorders in HIV: a systematic reviewNegin Farhadian0Sajad Moradi1Mohammad Hossein Zamanian2Vahid Farnia3Shahab Rezaeian4Maryam Farhadian5Mohsen Shahlaei6Substance Abuse Prevention Research Center, Health Institute, Kermanshah University of Medical SciencesNano Drug Delivery Research Center, Health Technology Institute, Kermanshah University of Medical SciencesDepartment of Infection Disease, Faculty of Medicine, Kermanshah University of Medical SciencesSubstance Abuse Prevention Research Center, Health Institute, Kermanshah University of Medical SciencesResearch Center for Environmental Determinants of Health (RCEDH), Health Institute, Kermanshah University of Medical SciencesDepartment of Biostatistics, School of Public Health and Research Center for Health Sciences, Hamadan University of Medical SciencesNano Drug Delivery Research Center, Health Technology Institute, Kermanshah University of Medical SciencesAbstract Background Because alcohol use disorders (AUDs) in patients living with HIV/AIDS are associated with a reduction in therapeutic outcomes and increases the risk of morbidity/mortality, finding an appropriate pharmacotherapy treatment for this disorder is necessary. Objectives This systematic review contains studies that examine the effects of pharmacological intervention (oral naltrexone (NTX) or injectable extended-release naltrexone (XR-NTX)) on the persons living with HIV and AUDs. Methods A systematic literature search using three electronic databases including Pubmed Medline, Scopus and the Cochrane Library and Google Scholar was conducted and includes articles published from 1995 to 2019. Records were collected by searching relevant keywords and those that meet the inclusion/exclusion criteria are included. Results Overall, in this systematic review, the results of 7 relevant studies including pilot and randomized controlled/clinical trials were summarized and reviewed. Among selected records 2 of these assessed the efficacy of NTX and 5 tested the XR-NTX effectiveness in treating AUDs among persons living with HIV (PLH). In summary, with some expectations, NTX and XR-NTX administration in persons living with HIV and AUDs led to reduced alcohol use, improved viral suppression, unchanged ART adherence and has no significant adverse events. Conclusion The findings of this systematic review suggest the beneficial effects and safety of the NTX and XR-NTX for treating AUDs in PLH. Further studies are needed in the future to focus on the treatment of AUDs in people living with HIV.http://link.springer.com/article/10.1186/s13011-020-00266-6Alcohol use disorders (AUDs)HIVNaltrexoneSystematic reviewTreatment |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Negin Farhadian Sajad Moradi Mohammad Hossein Zamanian Vahid Farnia Shahab Rezaeian Maryam Farhadian Mohsen Shahlaei |
spellingShingle |
Negin Farhadian Sajad Moradi Mohammad Hossein Zamanian Vahid Farnia Shahab Rezaeian Maryam Farhadian Mohsen Shahlaei Effectiveness of naltrexone treatment for alcohol use disorders in HIV: a systematic review Substance Abuse Treatment, Prevention, and Policy Alcohol use disorders (AUDs) HIV Naltrexone Systematic review Treatment |
author_facet |
Negin Farhadian Sajad Moradi Mohammad Hossein Zamanian Vahid Farnia Shahab Rezaeian Maryam Farhadian Mohsen Shahlaei |
author_sort |
Negin Farhadian |
title |
Effectiveness of naltrexone treatment for alcohol use disorders in HIV: a systematic review |
title_short |
Effectiveness of naltrexone treatment for alcohol use disorders in HIV: a systematic review |
title_full |
Effectiveness of naltrexone treatment for alcohol use disorders in HIV: a systematic review |
title_fullStr |
Effectiveness of naltrexone treatment for alcohol use disorders in HIV: a systematic review |
title_full_unstemmed |
Effectiveness of naltrexone treatment for alcohol use disorders in HIV: a systematic review |
title_sort |
effectiveness of naltrexone treatment for alcohol use disorders in hiv: a systematic review |
publisher |
BMC |
series |
Substance Abuse Treatment, Prevention, and Policy |
issn |
1747-597X |
publishDate |
2020-03-01 |
description |
Abstract Background Because alcohol use disorders (AUDs) in patients living with HIV/AIDS are associated with a reduction in therapeutic outcomes and increases the risk of morbidity/mortality, finding an appropriate pharmacotherapy treatment for this disorder is necessary. Objectives This systematic review contains studies that examine the effects of pharmacological intervention (oral naltrexone (NTX) or injectable extended-release naltrexone (XR-NTX)) on the persons living with HIV and AUDs. Methods A systematic literature search using three electronic databases including Pubmed Medline, Scopus and the Cochrane Library and Google Scholar was conducted and includes articles published from 1995 to 2019. Records were collected by searching relevant keywords and those that meet the inclusion/exclusion criteria are included. Results Overall, in this systematic review, the results of 7 relevant studies including pilot and randomized controlled/clinical trials were summarized and reviewed. Among selected records 2 of these assessed the efficacy of NTX and 5 tested the XR-NTX effectiveness in treating AUDs among persons living with HIV (PLH). In summary, with some expectations, NTX and XR-NTX administration in persons living with HIV and AUDs led to reduced alcohol use, improved viral suppression, unchanged ART adherence and has no significant adverse events. Conclusion The findings of this systematic review suggest the beneficial effects and safety of the NTX and XR-NTX for treating AUDs in PLH. Further studies are needed in the future to focus on the treatment of AUDs in people living with HIV. |
topic |
Alcohol use disorders (AUDs) HIV Naltrexone Systematic review Treatment |
url |
http://link.springer.com/article/10.1186/s13011-020-00266-6 |
work_keys_str_mv |
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