Risk of post-discharge fall-related injuries among adult patients with syncope: A nationwide cohort study.
BACKGROUND:Syncope could be related to high risk of falls and injury in adults, but documentation is sparse. We examined the association between syncope and subsequent fall-related injuries in a nationwide cohort. METHODS:By cross-linkage of nationwide registers, all residents ≥18 years with a first...
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doaj-eb1a6cff92c74b8b8bebbc690cd8337f2020-11-25T01:25:28ZengPublic Library of Science (PLoS)PLoS ONE1932-62032018-01-011311e020693610.1371/journal.pone.0206936Risk of post-discharge fall-related injuries among adult patients with syncope: A nationwide cohort study.Anna-Karin NuméNicolas CarlsonThomas A GerdsEllen HolmJannik PallisgaardKathrine B SøndergaardMorten L HansenMichael VintherJim HansenGunnar GislasonChristian Torp-PedersenMartin H RuwaldBACKGROUND:Syncope could be related to high risk of falls and injury in adults, but documentation is sparse. We examined the association between syncope and subsequent fall-related injuries in a nationwide cohort. METHODS:By cross-linkage of nationwide registers, all residents ≥18 years with a first-time diagnosis of syncope were identified between 1997-2012. Syncope patients were matched 1:1 with individuals from the general population. The absolute one-year risk of fall-related injuries, defined as fractures and traumatic head injuries requiring hospitalization, was calculated using Aalen-Johansen estimator. Ratios of the absolute one-year risk of fall-related injuries (ARR) were assessed by absolute risk regression analysis. RESULTS:We identified 125,763 patients with syncope: median age 65 years (interquartile range 46-78). At one year, follow-up was complete for 99.8% where a total of 8394 (6.7%) patients sustained a fall-related injury requiring hospitalization, of which 1606 (19.1%) suffered hip fracture. In the reference group, 4049 (3.2%) persons had a fall-related injury. The one-year ARR of a fall-related injury was 1.79 (95% confidence interval 1.72-1.87, P<0.001) in patients with syncope compared with the reference group; however, increased ARR was not exclusively in older patients. Factors independently associated with increased ARR of fall-related injuries in the syncope population were: injury in past 12 months, 2.39 (2.26-2.53, P<0.001), injury in relation to the syncope episode, 1.62 (1.49-1.77, P<0.001), and depression, 1.37 (1.30-1.45, P<0.001). CONCLUSION:Patients with syncope were at 80% increased risk of severe fall-related injuries within the year following discharge. Notably, increased risk was not exclusively in older patients.http://europepmc.org/articles/PMC6248940?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Anna-Karin Numé Nicolas Carlson Thomas A Gerds Ellen Holm Jannik Pallisgaard Kathrine B Søndergaard Morten L Hansen Michael Vinther Jim Hansen Gunnar Gislason Christian Torp-Pedersen Martin H Ruwald |
spellingShingle |
Anna-Karin Numé Nicolas Carlson Thomas A Gerds Ellen Holm Jannik Pallisgaard Kathrine B Søndergaard Morten L Hansen Michael Vinther Jim Hansen Gunnar Gislason Christian Torp-Pedersen Martin H Ruwald Risk of post-discharge fall-related injuries among adult patients with syncope: A nationwide cohort study. PLoS ONE |
author_facet |
Anna-Karin Numé Nicolas Carlson Thomas A Gerds Ellen Holm Jannik Pallisgaard Kathrine B Søndergaard Morten L Hansen Michael Vinther Jim Hansen Gunnar Gislason Christian Torp-Pedersen Martin H Ruwald |
author_sort |
Anna-Karin Numé |
title |
Risk of post-discharge fall-related injuries among adult patients with syncope: A nationwide cohort study. |
title_short |
Risk of post-discharge fall-related injuries among adult patients with syncope: A nationwide cohort study. |
title_full |
Risk of post-discharge fall-related injuries among adult patients with syncope: A nationwide cohort study. |
title_fullStr |
Risk of post-discharge fall-related injuries among adult patients with syncope: A nationwide cohort study. |
title_full_unstemmed |
Risk of post-discharge fall-related injuries among adult patients with syncope: A nationwide cohort study. |
title_sort |
risk of post-discharge fall-related injuries among adult patients with syncope: a nationwide cohort study. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2018-01-01 |
description |
BACKGROUND:Syncope could be related to high risk of falls and injury in adults, but documentation is sparse. We examined the association between syncope and subsequent fall-related injuries in a nationwide cohort. METHODS:By cross-linkage of nationwide registers, all residents ≥18 years with a first-time diagnosis of syncope were identified between 1997-2012. Syncope patients were matched 1:1 with individuals from the general population. The absolute one-year risk of fall-related injuries, defined as fractures and traumatic head injuries requiring hospitalization, was calculated using Aalen-Johansen estimator. Ratios of the absolute one-year risk of fall-related injuries (ARR) were assessed by absolute risk regression analysis. RESULTS:We identified 125,763 patients with syncope: median age 65 years (interquartile range 46-78). At one year, follow-up was complete for 99.8% where a total of 8394 (6.7%) patients sustained a fall-related injury requiring hospitalization, of which 1606 (19.1%) suffered hip fracture. In the reference group, 4049 (3.2%) persons had a fall-related injury. The one-year ARR of a fall-related injury was 1.79 (95% confidence interval 1.72-1.87, P<0.001) in patients with syncope compared with the reference group; however, increased ARR was not exclusively in older patients. Factors independently associated with increased ARR of fall-related injuries in the syncope population were: injury in past 12 months, 2.39 (2.26-2.53, P<0.001), injury in relation to the syncope episode, 1.62 (1.49-1.77, P<0.001), and depression, 1.37 (1.30-1.45, P<0.001). CONCLUSION:Patients with syncope were at 80% increased risk of severe fall-related injuries within the year following discharge. Notably, increased risk was not exclusively in older patients. |
url |
http://europepmc.org/articles/PMC6248940?pdf=render |
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