Unexpected high frequency of neurofibroma in the celiac ganglion of German cattle
Abstract In a study originally designed to find potential risk factors for bovine spongiform encephalopathy (BSE) we examined tissues from 403 Holstein Frisian cattle in total. These included 20 BSE cattle and their 236 birth- and feeding cohort animals plus 32 offspring, 103 age, breed and district...
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doaj-eb1bc5c4e3ed4314a8e7c172625036992020-11-25T03:52:56ZengBMCVeterinary Research1297-97162020-06-0151111310.1186/s13567-020-00800-1Unexpected high frequency of neurofibroma in the celiac ganglion of German cattleInsa Dammann0Wiebke M. Wemheuer1Arne Wrede2Wilhelm E. Wemheuer3Amely Campe4Jutta Petschenka5Ulf Schulze-Sturm6Uwe Hahmann7Claus P. Czerny8Pia Münster9Bertram Brening10Lothar Kreienbrock11Christiane Herden12Walter J. Schulz-Schaeffer13Institute of Neuropathology, Medical Faculty of the Saarland UniversityInstitute of Neuropathology, Medical Faculty of the Saarland UniversityInstitute of Neuropathology, Medical Faculty of the Saarland UniversityInstitute of Veterinary Medicine, University of GoettingenDepartment for Biometry, Epidemiology and Information Processing (IBEI), University of Veterinary Medicine and WHO-Collaboration Centre for Research and Training at the Human-Animal-Environmental InterfaceBoehringer Ingelheim Pharma GmbH & Co. KG, Cancer Immunology & Immune ModulationDepartment of Paediatrics, University Medical Centre Hamburg-Eppendorf (UKE)Institute of Neuropathology, University Medical Center GoettingenInstitute of Veterinary Medicine, University of GoettingenInstitute of Veterinary Medicine, University of GoettingenInstitute of Veterinary Medicine, University of GoettingenDepartment for Biometry, Epidemiology and Information Processing (IBEI), University of Veterinary Medicine and WHO-Collaboration Centre for Research and Training at the Human-Animal-Environmental InterfaceInstitute of Pathology, Veterinary Faculty, Justus Liebig UniversityInstitute of Neuropathology, Medical Faculty of the Saarland UniversityAbstract In a study originally designed to find potential risk factors for bovine spongiform encephalopathy (BSE) we examined tissues from 403 Holstein Frisian cattle in total. These included 20 BSE cattle and their 236 birth- and feeding cohort animals plus 32 offspring, 103 age, breed and district-matched control cattle and further twelve cattle with neurological signs. In addition to the obex, we examined the celiac ganglion, cervical cranial ganglion, trigeminal ganglion and proximal ganglion of the vagus nerve using histological techniques. Unexpectedly, we found a high number of neurofibroma, a benign peripheral nerve sheath tumor consisting of Schwann cells, fibroblasts and perineural cells. The neurofibroma were present only in the celiac ganglion and found during histologic examination. With a frequency of 9.91% in BSE cattle and their cohorts (case animals) and 9.09% in the age, breed and district matched control animals there seems to be no correlation between the occurrence of BSE and neurofibroma. Benign peripheral nerve sheath tumors have been described more often in cattle than in other domestic animals. Usually, they are incidental macroscopic findings in the thoracic ganglia during meat inspection. To our knowledge, there are no previous systematic histologic studies including bovine celiac ganglia at all. The high incidence of celiac ganglia neurofibroma may play a role in the frequently occurring abomasal displacements in Holstein Frisian cattle as the tumors might cause a gastrointestinal motility disorder. At present a genetic predisposition for these neoplasms cannot be ruled out.http://link.springer.com/article/10.1186/s13567-020-00800-1 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Insa Dammann Wiebke M. Wemheuer Arne Wrede Wilhelm E. Wemheuer Amely Campe Jutta Petschenka Ulf Schulze-Sturm Uwe Hahmann Claus P. Czerny Pia Münster Bertram Brening Lothar Kreienbrock Christiane Herden Walter J. Schulz-Schaeffer |
spellingShingle |
Insa Dammann Wiebke M. Wemheuer Arne Wrede Wilhelm E. Wemheuer Amely Campe Jutta Petschenka Ulf Schulze-Sturm Uwe Hahmann Claus P. Czerny Pia Münster Bertram Brening Lothar Kreienbrock Christiane Herden Walter J. Schulz-Schaeffer Unexpected high frequency of neurofibroma in the celiac ganglion of German cattle Veterinary Research |
author_facet |
Insa Dammann Wiebke M. Wemheuer Arne Wrede Wilhelm E. Wemheuer Amely Campe Jutta Petschenka Ulf Schulze-Sturm Uwe Hahmann Claus P. Czerny Pia Münster Bertram Brening Lothar Kreienbrock Christiane Herden Walter J. Schulz-Schaeffer |
author_sort |
Insa Dammann |
title |
Unexpected high frequency of neurofibroma in the celiac ganglion of German cattle |
title_short |
Unexpected high frequency of neurofibroma in the celiac ganglion of German cattle |
title_full |
Unexpected high frequency of neurofibroma in the celiac ganglion of German cattle |
title_fullStr |
Unexpected high frequency of neurofibroma in the celiac ganglion of German cattle |
title_full_unstemmed |
Unexpected high frequency of neurofibroma in the celiac ganglion of German cattle |
title_sort |
unexpected high frequency of neurofibroma in the celiac ganglion of german cattle |
publisher |
BMC |
series |
Veterinary Research |
issn |
1297-9716 |
publishDate |
2020-06-01 |
description |
Abstract In a study originally designed to find potential risk factors for bovine spongiform encephalopathy (BSE) we examined tissues from 403 Holstein Frisian cattle in total. These included 20 BSE cattle and their 236 birth- and feeding cohort animals plus 32 offspring, 103 age, breed and district-matched control cattle and further twelve cattle with neurological signs. In addition to the obex, we examined the celiac ganglion, cervical cranial ganglion, trigeminal ganglion and proximal ganglion of the vagus nerve using histological techniques. Unexpectedly, we found a high number of neurofibroma, a benign peripheral nerve sheath tumor consisting of Schwann cells, fibroblasts and perineural cells. The neurofibroma were present only in the celiac ganglion and found during histologic examination. With a frequency of 9.91% in BSE cattle and their cohorts (case animals) and 9.09% in the age, breed and district matched control animals there seems to be no correlation between the occurrence of BSE and neurofibroma. Benign peripheral nerve sheath tumors have been described more often in cattle than in other domestic animals. Usually, they are incidental macroscopic findings in the thoracic ganglia during meat inspection. To our knowledge, there are no previous systematic histologic studies including bovine celiac ganglia at all. The high incidence of celiac ganglia neurofibroma may play a role in the frequently occurring abomasal displacements in Holstein Frisian cattle as the tumors might cause a gastrointestinal motility disorder. At present a genetic predisposition for these neoplasms cannot be ruled out. |
url |
http://link.springer.com/article/10.1186/s13567-020-00800-1 |
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