Increased mitochondrial fusion allows the survival of older animals in diverse C. elegans longevity pathways

Increased mitochondrial fusion allows the survival of older animals in diverse C. elegans longevity pathways

Mitochondria can undergo shape changes as a result of fusion and fission events. Here the authors describe how insulin signalling regulates mitochondrial fusion in C. elegans, and show that mitochondrial fusion is necessary, but not sufficient, for longevity of worms with mutations that increase lif...

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Main Authors: Snehal N. Chaudhari, Edward T. Kipreos
Format: Article
Language:English
Published: Nature Publishing Group 2017-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-00274-4
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spelling doaj-eb3d10986971495c9e8d4a385fe441a12021-01-31T12:32:03ZengNature Publishing GroupNature Communications2041-17232017-08-018111610.1038/s41467-017-00274-4Increased mitochondrial fusion allows the survival of older animals in diverse C. elegans longevity pathwaysSnehal N. Chaudhari0Edward T. Kipreos1Department of Cellular Biology, The University of GeorgiaDepartment of Cellular Biology, The University of GeorgiaMitochondria can undergo shape changes as a result of fusion and fission events. Here the authors describe how insulin signalling regulates mitochondrial fusion in C. elegans, and show that mitochondrial fusion is necessary, but not sufficient, for longevity of worms with mutations that increase lifespan.https://doi.org/10.1038/s41467-017-00274-4
collection DOAJ
language English
format Article
sources DOAJ
author Snehal N. Chaudhari
Edward T. Kipreos
spellingShingle Snehal N. Chaudhari
Edward T. Kipreos
Increased mitochondrial fusion allows the survival of older animals in diverse C. elegans longevity pathways
Nature Communications
author_facet Snehal N. Chaudhari
Edward T. Kipreos
author_sort Snehal N. Chaudhari
title Increased mitochondrial fusion allows the survival of older animals in diverse C. elegans longevity pathways
title_short Increased mitochondrial fusion allows the survival of older animals in diverse C. elegans longevity pathways
title_full Increased mitochondrial fusion allows the survival of older animals in diverse C. elegans longevity pathways
title_fullStr Increased mitochondrial fusion allows the survival of older animals in diverse C. elegans longevity pathways
title_full_unstemmed Increased mitochondrial fusion allows the survival of older animals in diverse C. elegans longevity pathways
title_sort increased mitochondrial fusion allows the survival of older animals in diverse c. elegans longevity pathways
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2017-08-01
description Mitochondria can undergo shape changes as a result of fusion and fission events. Here the authors describe how insulin signalling regulates mitochondrial fusion in C. elegans, and show that mitochondrial fusion is necessary, but not sufficient, for longevity of worms with mutations that increase lifespan.
url https://doi.org/10.1038/s41467-017-00274-4
work_keys_str_mv AT snehalnchaudhari increasedmitochondrialfusionallowsthesurvivalofolderanimalsindiverseceleganslongevitypathways
AT edwardtkipreos increasedmitochondrialfusionallowsthesurvivalofolderanimalsindiverseceleganslongevitypathways
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