Human papillomavirus variants among Inuit women in northern Quebec, Canada
Background: Inuit communities in northern Quebec have high rates of human papillomavirus (HPV) infection, cervical cancer and cervical cancer–related mortality as compared to the Canadian population. HPV types can be further classified as intratypic variants based on the extent of homology in their...
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doaj-eb40f831058b4b4db407162bf37e7ed22020-11-25T01:28:16ZengTaylor & Francis GroupInternational Journal of Circumpolar Health2242-39822015-12-017401710.3402/ijch.v74.2948229482Human papillomavirus variants among Inuit women in northern Quebec, CanadaBarbara Gauthier0Francois Coutlée1Eduardo L. Franco2Paul Brassard3 Department of Epidemiology, Biostatistics, and Occupational Health, McGill University, Montréal, QC, Canada Département de Microbiologie et Infectiologie, Centre Hospitalier de l'Université de Montréal, Montréal, QC, Canada Division of Cancer Epidemiology, McGill University, Montréal, QC, Canada Departments of Medicine and of Epidemiology, Biostatistics, and Occupational Health, McGill University, Montréal, QC, CanadaBackground: Inuit communities in northern Quebec have high rates of human papillomavirus (HPV) infection, cervical cancer and cervical cancer–related mortality as compared to the Canadian population. HPV types can be further classified as intratypic variants based on the extent of homology in their nucleotide sequences. There is limited information on the distribution of intratypic variants in circumpolar areas. Objective: Our goal was to describe the HPV intratypic variants and associated baseline characteristics. Design: We collected cervical cell samples in 2002–2006 from 676 Inuit women between the ages of 15 and 69 years in Nunavik. DNA isolates from high-risk HPVs were sequenced to determine the intratypic variant. Results: There were 149 women that were positive for HPVs 16, 18, 31, 33, 35, 45, 52, 56 or 58 during follow-up. There were 5 different HPV16 variants, all of European lineage, among the 57 women positive for this type. There were 8 different variants of HPV18 present and all were of European lineage (n=21). The majority of samples of HPV31 (n=52) were of lineage B. The number of isolates and diversity of the other HPV types was low. Age was the only covariate associated with HPV16 variant category. Conclusions: These frequencies are similar to what was seen in another circumpolar region of Canada, although there appears to be less diversity as only European variants were detected. This study shows that most variants were clustered in one lineage for each HPV type.http://www.circumpolarhealthjournal.net/index.php/ijch/article/view/29482/pdf_57infectious diseaseaboriginal healthviral geneticsepidemiologyInuitcervical cancer |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Barbara Gauthier Francois Coutlée Eduardo L. Franco Paul Brassard |
spellingShingle |
Barbara Gauthier Francois Coutlée Eduardo L. Franco Paul Brassard Human papillomavirus variants among Inuit women in northern Quebec, Canada International Journal of Circumpolar Health infectious disease aboriginal health viral genetics epidemiology Inuit cervical cancer |
author_facet |
Barbara Gauthier Francois Coutlée Eduardo L. Franco Paul Brassard |
author_sort |
Barbara Gauthier |
title |
Human papillomavirus variants among Inuit women in northern Quebec, Canada |
title_short |
Human papillomavirus variants among Inuit women in northern Quebec, Canada |
title_full |
Human papillomavirus variants among Inuit women in northern Quebec, Canada |
title_fullStr |
Human papillomavirus variants among Inuit women in northern Quebec, Canada |
title_full_unstemmed |
Human papillomavirus variants among Inuit women in northern Quebec, Canada |
title_sort |
human papillomavirus variants among inuit women in northern quebec, canada |
publisher |
Taylor & Francis Group |
series |
International Journal of Circumpolar Health |
issn |
2242-3982 |
publishDate |
2015-12-01 |
description |
Background: Inuit communities in northern Quebec have high rates of human papillomavirus (HPV) infection, cervical cancer and cervical cancer–related mortality as compared to the Canadian population. HPV types can be further classified as intratypic variants based on the extent of homology in their nucleotide sequences. There is limited information on the distribution of intratypic variants in circumpolar areas. Objective: Our goal was to describe the HPV intratypic variants and associated baseline characteristics. Design: We collected cervical cell samples in 2002–2006 from 676 Inuit women between the ages of 15 and 69 years in Nunavik. DNA isolates from high-risk HPVs were sequenced to determine the intratypic variant. Results: There were 149 women that were positive for HPVs 16, 18, 31, 33, 35, 45, 52, 56 or 58 during follow-up. There were 5 different HPV16 variants, all of European lineage, among the 57 women positive for this type. There were 8 different variants of HPV18 present and all were of European lineage (n=21). The majority of samples of HPV31 (n=52) were of lineage B. The number of isolates and diversity of the other HPV types was low. Age was the only covariate associated with HPV16 variant category. Conclusions: These frequencies are similar to what was seen in another circumpolar region of Canada, although there appears to be less diversity as only European variants were detected. This study shows that most variants were clustered in one lineage for each HPV type. |
topic |
infectious disease aboriginal health viral genetics epidemiology Inuit cervical cancer |
url |
http://www.circumpolarhealthjournal.net/index.php/ijch/article/view/29482/pdf_57 |
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