Severe Prolonged Hypothyroidism
Background . Hashimoto’s thyroiditis usually presents with nonspecific systemic symptoms. The purpose of our study was to characterize the various properties of severe ongoing hypothyroidism and the rate of normalization following treatment. Methods . An adolescent girl with severe primary hypothyro...
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2015-03-01
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Series: | Global Pediatric Health |
Online Access: | https://doi.org/10.1177/2333794X15574679 |
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doaj-eb46ce60ad364f429e068c181a9b98ba2020-11-25T04:02:52ZengSAGE PublishingGlobal Pediatric Health2333-794X2015-03-01210.1177/2333794X1557467910.1177_2333794X15574679Severe Prolonged HypothyroidismYonatan Yeshayahu MD, MHA0Shirly Frizinsky MD1Raz Somech MD, PhD2Gal Dubnov-Raz MD, MSc3Faculty of Medicine, Tel-Aviv University, IsraelDepartment of Pediatrics B, Edmond and Lily Safra Children’s Hospital, Sheba Medical Center, Ramat Gan, IsraelFaculty of Medicine, Tel-Aviv University, IsraelFaculty of Medicine, Tel-Aviv University, IsraelBackground . Hashimoto’s thyroiditis usually presents with nonspecific systemic symptoms. The purpose of our study was to characterize the various properties of severe ongoing hypothyroidism and the rate of normalization following treatment. Methods . An adolescent girl with severe primary hypothyroidism was studied. Clinical evaluation, laboratory testing, brain magnetic resonance imaging, resting metabolic rate (RMR) testing, electroencephalogram, and visual field examination were performed at baseline and following treatment with levothyroxine. Results . At baseline, a significant psychomotor retardation was observed, serum thyroid-stimulating hormone concentration was 1088.4 mIU/mL. Magnetic resonance imaging showed a large intrasellar mass. Electroencephalogram was abnormal, and RMR was significantly reduced. Restoration of neurocognitive function and normalization of RMR, electroencephalogram, and laboratory tests occurred rapidly, alongside vanishing of the pituitary mass within 4 weeks of treatment. Conclusions . The various signs and symptoms of severe prolonged hypothyroidism may resolve rapidly with treatment, including the disappearance of a large pituitary mass.https://doi.org/10.1177/2333794X15574679 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yonatan Yeshayahu MD, MHA Shirly Frizinsky MD Raz Somech MD, PhD Gal Dubnov-Raz MD, MSc |
spellingShingle |
Yonatan Yeshayahu MD, MHA Shirly Frizinsky MD Raz Somech MD, PhD Gal Dubnov-Raz MD, MSc Severe Prolonged Hypothyroidism Global Pediatric Health |
author_facet |
Yonatan Yeshayahu MD, MHA Shirly Frizinsky MD Raz Somech MD, PhD Gal Dubnov-Raz MD, MSc |
author_sort |
Yonatan Yeshayahu MD, MHA |
title |
Severe Prolonged Hypothyroidism |
title_short |
Severe Prolonged Hypothyroidism |
title_full |
Severe Prolonged Hypothyroidism |
title_fullStr |
Severe Prolonged Hypothyroidism |
title_full_unstemmed |
Severe Prolonged Hypothyroidism |
title_sort |
severe prolonged hypothyroidism |
publisher |
SAGE Publishing |
series |
Global Pediatric Health |
issn |
2333-794X |
publishDate |
2015-03-01 |
description |
Background . Hashimoto’s thyroiditis usually presents with nonspecific systemic symptoms. The purpose of our study was to characterize the various properties of severe ongoing hypothyroidism and the rate of normalization following treatment. Methods . An adolescent girl with severe primary hypothyroidism was studied. Clinical evaluation, laboratory testing, brain magnetic resonance imaging, resting metabolic rate (RMR) testing, electroencephalogram, and visual field examination were performed at baseline and following treatment with levothyroxine. Results . At baseline, a significant psychomotor retardation was observed, serum thyroid-stimulating hormone concentration was 1088.4 mIU/mL. Magnetic resonance imaging showed a large intrasellar mass. Electroencephalogram was abnormal, and RMR was significantly reduced. Restoration of neurocognitive function and normalization of RMR, electroencephalogram, and laboratory tests occurred rapidly, alongside vanishing of the pituitary mass within 4 weeks of treatment. Conclusions . The various signs and symptoms of severe prolonged hypothyroidism may resolve rapidly with treatment, including the disappearance of a large pituitary mass. |
url |
https://doi.org/10.1177/2333794X15574679 |
work_keys_str_mv |
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